NR5A2 Activators
NR5A2 activators consist of a group of compounds that can indirectly influence the activity of NR5A2 by modulating various cellular and molecular pathways. These compounds can affect the regulatory regions of genes controlled by NR5A2 or the transcriptional machinery itself. For example, agonists of the Liver X Receptor (LXR), such as GW3965 and T0901317, can enhance the expression of genes involved in lipid and cholesterol homeostasis, which are also under the regulatory domain of NR5A2. By upregulating these pathways, these compounds indirectly elevate NR5A2 activity.
Additionally, molecules like cholestyramine and statins, which alter cholesterol and bile acid metabolism, could lead to compensatory regulatory effects on NR5A2. This is because NR5A2 is a crucial component in the homeostatic feedback loops that maintain cholesterol levels within the cell. Compounds that modulate lipid metabolism, such as PPARα agonists, might also affect NR5A2 activity indirectly by influencing the expression of genes within the same pathways that NR5A2 regulates.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 3965 hydrochloride | 405911-17-3 | sc-224011 sc-224011A sc-224011B | 5 mg 25 mg 1 g | $137.00 $474.00 $3060.00 | ||
Liver X receptor (LXR) agonist that may upregulate the expression of genes involved in cholesterol metabolism, indirectly affecting NR5A2. | ||||||
T 0901317 | 293754-55-9 | sc-202824 sc-202824A | 10 mg 50 mg | $87.00 $220.00 | 5 | |
LXR agonist that can influence lipid metabolism regulatory genes, potentially increasing NR5A2 activity. | ||||||
CHOLESTYRAMINE RESIN | 11041-12-6 | sc-507509 | 5 g | $210.00 | ||
Bile acid sequestrant that can lead to compensatory upregulation of cholesterol synthesis genes, possibly affecting NR5A2. | ||||||
Rosuvastatin | 287714-41-4 | sc-481834 | 10 mg | $142.00 | 8 | |
Statin that inhibits HMG-CoA reductase, potentially upregulating NR5A2 due to feedback mechanisms in cholesterol synthesis. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
PPARα agonist that modulates lipid metabolism, potentially affecting NR5A2-regulated genes. | ||||||
Guggulsterone | 95975-55-6 | sc-203990 sc-203990A | 10 mg 50 mg | $145.00 $615.00 | 1 | |
A phytosteroid that has been reported to modulate cholesterol metabolism, which could affect NR5A2 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Can modulate gene expression and might influence NR5A2 through pathways related to cellular differentiation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor that could alter gene expression patterns, potentially affecting NR5A2 activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor that may influence chromatin structure and gene expression, potentially affecting NR5A2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator that raises cAMP levels, which might lead to changes in gene expression affecting NR5A2. | ||||||