NPR-B Activators
The chemical class of NPR-B activators encompasses a diverse array of compounds that exert effects through direct or indirect modulation of the natriuretic peptide receptor B (NPR-B) signaling pathway, pivotal in regulating cardiovascular homeostasis and fluid balance. Forskolin, found in Coleus forskohlii, activates adenylate cyclase, elevating intracellular cAMP levels. This increase indirectly activates NPR-B by modulating downstream signaling pathways, such as protein kinase A (PKA).
Compounds like YC-1, Bay 41-2272, and Riociguat stimulate soluble guanylate cyclase (sGC), leading to heightened cGMP production, impacting NPR-B activity through cGMP-dependent pathways. These compounds have been explored for their involvement in cardiovascular disorders. Nitric oxide donors like Nitroglycerin and guanosine, a nucleoside, contribute to cGMP synthesis, indirectly influencing NPR-B activity. The class also includes synthetic compounds like Cinaciguat, Vericiguat, and 8-Bromo-cGMP, directly or indirectly impacting NPR-B through modulation of cGMP-dependent pathways. The unique mechanisms of these NPR-B activators underscore the intricate and versatile nature of signaling pathways involved in cardiovascular regulation, providing valuable insights for further research and interventions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpene found in the Indian plant Coleus forskohlii. It activates adenylate cyclase, leading to an increase in intracellular cAMP levels. This elevation of cAMP can indirectly activate NPR-B by modulating downstream signaling pathways such as PKA. | ||||||
YC-1 | 170632-47-0 | sc-202856 sc-202856A sc-202856B sc-202856C | 1 mg 5 mg 10 mg 50 mg | $33.00 $124.00 $218.00 $947.00 | 9 | |
YC-1 is a synthetic compound known to activate soluble guanylate cyclase (sGC). Through sGC activation, YC-1 increases cGMP levels, indirectly influencing NPR-B activity. This chemical has been investigated for its potential in modulating the nitric oxide-cGMP signaling pathway. | ||||||
BAY 41-2272 | 256376-24-6 | sc-202491 sc-202491A | 5 mg 25 mg | $238.00 $728.00 | 4 | |
Bay 41-2272 is a stimulator of soluble guanylate cyclase (sGC). By enhancing sGC activity, it promotes the synthesis of cGMP, leading to downstream effects that can indirectly activate NPR-B. This compound has been explored for its vasodilatory effects mediated through the NO-cGMP pathway. | ||||||
Riociguat | 625115-55-1 | sc-476845 | 5 mg | $300.00 | ||
Riociguat is a sGC stimulator used in treating pulmonary hypertension. Through its action on sGC, Riociguat increases cGMP levels, potentially impacting NPR-B activity indirectly by modulating the cGMP-dependent signaling pathways associated with natriuretic peptide receptors. | ||||||
Guanosine | 118-00-3 | sc-218575 sc-218575A sc-218575B sc-218575C sc-218575D | 5 g 25 g 250 g 1 kg 5 kg | $40.00 $50.00 $84.00 $250.00 $1103.00 | ||
Guanosine, a nucleoside, can indirectly activate NPR-B by serving as a precursor for cGMP synthesis. Through its conversion to guanosine monophosphate (GMP) and subsequent processing, it contributes to the pool of intracellular cGMP, impacting NPR-B activity through cGMP-dependent pathways. | ||||||
8-Bromo-cGMP | 51116-01-9 | sc-200316 sc-200316A | 10 mg 50 mg | $104.00 $354.00 | 7 | |
8-Bromo-cGMP is a cell-permeable analog of cGMP. Its application can directly influence NPR-B by mimicking the effects of endogenous cGMP. This compound has been used in research to explore the specific cellular responses mediated by cGMP, potentially impacting NPR-B activity in a controlled manner. | ||||||