BAY 41-2272 CAS: 256376-24-6
MF: C20H17FN6
MW: 360.39
A pyrazolopyridinylpyrimidine compound with potent stimulator effects on soluble guanylate cyclase.

BAY 41-2272 (CAS 256376-24-6)

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Synonym: 3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine
Application: A pyrazolopyridinylpyrimidine compound with potent stimulator effects on soluble guanylate cyclase
CAS Number: 256376-24-6
Purity: ≥98%
Molecular Weight: 360.39
Molecular Formula: C20H17FN6
* Refer to Certificate of Analysis for lot specific data (including water content).
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BAY 41-2272 is a pyrazolopyridinylpyrimidine compound with selective and potent stimulator effects on soluble guanylate cyclase (sGC). This product sensitizes sGC to nitric oxide (NO), its physiological stimulator, and contains antiplatelet activity. BAY 41-2272 is an inhibitor of GCS.


References

1. Becker, E.M., et al. 2001. BMC Pharmacol. 1: 13. PMID: 11801189
2. Stasch, J.P., et al. 2001. Nature. 410: 212-215. PMID: 11242081
3. Boerrigter, G., et al. 2003. Circulation. 107: 686-689. PMID: 12578869

Appearance :
Needles
Physical State :
Solid
Solubility :
Soluble in DMSO (26 mg/ml) at 60° C, dichloromethane, 100% ethanol, and 2-pyrrolidone. Practically insoluble in water.
Storage :
Store at 4° C
Melting Point :
210.5-211.4° C
Boiling Point :
496.08° C at 760 mmHg
Density :
1.49 g/cm3
Refractive Index :
n20D 1.77
IC50 :
phenylephrine-induced constriction: IC50 = 304 nM (rabbit); collagen-induced aggregation: IC50 = 36 nM (human platelets)
pK Values :
pKb: 2.71
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9798973
MDL Number :
MFCD06411391
SMILES :
C1CC1C2=CN=C(N=C2N)C3=NN(C4=C3C=CC=N4)CC5=CC=CC=C5F

Download SDS (MSDS)

Certificate of Analysis

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BAY 41-2272  Product Citations

See how others have used BAY 41-2272. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 11944922  Koglin, M. et al. 2002. Biochem. Biophys. Res. Commun. 292: 1057-1062.

Citations 1 to 1 of 1 total

What does it dissolve in? Does it dissolve in water?

Asked by: Nalan
Thank you for your question. BAY 41-2272 is practically insoluble in water. It is soluble in DMSO (26 mg/ml at 60 C), dicholormethane, 100% ethanol or 2-pyrrolidone. Please contact Technical Support for for additional questions vial email ([email protected]), phone (800-457-3801 option 2) or chat (www.scbt.com).
Answered by: Santa Cruz TS
Date published: 2017-05-22
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