NPN Activators
Nephrocan Activators represent a diverse chemical class of compounds that modulate cellular signaling pathways and extracellular matrix organization. These activators do not directly interact with NPN but instead influence the cellular environment or gene expression patterns which NPN is involved in. The primary mechanism by which these compounds can activate NPN is through their impact on secondary messengers, transcription factors, and enzymes that are related to extracellular matrix dynamics, including its formation, stabilization, and degradation. For instance, Forskolin enhances cAMP levels, which can activate PKA and subsequently modulate the extracellular matrix, while other compounds like Genistein and EGCG impact kinase activity and enzyme function, respectively.
Each activator in its unique way contributes to the regulation of pathways implicating NPN function. Dexamethasone, through its modulation of transcription, can influence pathways that NPN acts upstream of or within, such as the negative regulation of transcription by RNA polymerase II. In contrast, compounds like Ascorbic Acid have a more supportive role in extracellular matrix formation, thus indirectly affecting the interstitial matrix organization and potentially the activity of NPN. Collectively, these chemicals, by altering the synthesis, structure, and signaling within the extracellular space, can have a downstream impact on the operational dynamics of NPN, even though their primary sites of action are not on NPN itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, resulting in increased production of cyclic AMP (cAMP), which is a secondary messenger known to enhance the activation of protein kinase A (PKA). PKA can phosphorylate multiple substrates, potentially leading to the modulation of extracellular matrix organization which NPN (nephrocan) is involved in. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol (DAG) analogue that activates protein kinase C (PKC), leading to altered cell signaling. PKC has been implicated in the regulation of transcription and could possibly affect the extracellular matrix organization, indirectly influencing NPN activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates gene expression through retinoic acid receptors. It can affect the expression of genes involved in the extracellular matrix organization and may have an indirect effect on NPN function. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid that acts as a transcriptional regulator. It has the ability to modulate various signaling pathways, including the negative regulation of transcription by RNA polymerase II, which could influence NPN activity within its regulatory context. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic acid is essential for collagen biosynthesis and extracellular matrix formation. By supporting the formation and stability of the interstitial matrix where NPN operates, it may indirectly affect NPN's activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can alter signal transduction pathways. By inhibiting certain kinases, it may influence the extracellular matrix organization and indirectly affect the functionality of NPN. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits matrix metalloproteinases which are involved in extracellular matrix degradation. By inhibiting these enzymes, EGCG can stabilize the matrix environment, potentially affecting NPN's activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate the expression of various transcription factors and cytokines, leading to an altered extracellular matrix organization. This can indirectly influence the function of NPN. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol influences sirtuin activity and modulates several signaling pathways, including those related to extracellular matrix organization. This could indirectly impact NPN's activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate is a histone deacetylase inhibitor that leads to the hyperacetylation of histones, affecting chromatin structure and gene expression. This can modulate extracellular matrix-related genes, potentially influencing NPN. | ||||||