NNT Inhibitors
NNT inhibitors, short for Nicotinamide Nucleotide Transhydrogenase inhibitors, belong to a significant class of chemical compounds that target a specific enzyme involved in cellular energy metabolism. These inhibitors are designed to modulate the activity of the Nicotinamide Nucleotide Transhydrogenase (NNT) enzyme, which plays a crucial role in the transfer of electrons between the nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH) coenzymes. NNT is primarily found in the inner mitochondrial membrane of eukaryotic cells, where it participates in the maintenance of the cellular redox balance and the generation of NADPH, a critical molecule in various cellular processes.
NNT inhibitors are diverse and can encompass a wide range of chemical compounds, each with unique properties that affect the enzyme's activity. These inhibitors typically interact with NNT through specific binding sites, disrupting its normal function. By inhibiting NNT, these compounds alter the ratio of NADH to NADPH, which has implications for cellular energy production and oxidative stress regulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10, also known as ubiquinone, can inhibit NNT by accepting electrons directly from it, thus potentially bypassing its normal function in the mitochondrial electron transport chain. | ||||||
Atovaquone | 95233-18-4 | sc-217675 | 10 mg | $270.00 | 2 | |
Atovaquone can inhibit NNT by binding to the ubiquinone binding site within the mitochondria, disrupting the normal electron flow and inhibiting NNT's function in the electron transport chain. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone can inhibit NNT by binding to complex I of the mitochondrial electron transport chain, where NNT is localized, and obstructing electron transfer. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $291.00 | 24 | |
Piericidin A can inhibit NNT by acting as a competitive inhibitor to ubiquinone, hindering its interaction with NNT and thereby inhibiting the protein's function. | ||||||
Tolcapone | 134308-13-7 | sc-220266 | 10 mg | $167.00 | 1 | |
Tolcapone can inhibit NNT indirectly by its effect on the catecholamine pathway, leading to altered redox states that could impact NNT activity. | ||||||
Mito-Q | 444890-41-9 | sc-507441 | 5 mg | $290.00 | ||
Mitoquinone, a derivative of Coenzyme Q10, can inhibit NNT by targeting the mitochondria and altering the ubiquinone pool, thereby affecting NNT activity. | ||||||
Amitriptyline Hydrochloride | 549-18-8 | sc-210801 | 1 g | $200.00 | ||
Amitriptyline can inhibit NNT indirectly since it affects mitochondrial function, which may alter the oxidative stress environment that NNT is sensitive to. | ||||||
Diphenyleneiodonium chloride | 4673-26-1 | sc-202584E sc-202584 sc-202584D sc-202584A sc-202584B sc-202584C | 10 mg 25 mg 50 mg 100 mg 250 mg 500 mg | $151.00 $136.00 $317.00 $405.00 $944.00 $1837.00 | 24 | |
Diphenyleneiodonium can inhibit NNT by interfering with flavoproteins in the electron transport chain, thereby indirectly affecting NNT activity. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin can inhibit NNT indirectly by impacting complex I of the electron transport chain and altering mitochondrial function, thereby affecting NNT. | ||||||