NMDA epsilon 2 Inhibitors
Common NMDAε2 Inhibitors include, but are not limited to Dextromethorphan CAS 125-71-3, 1-Adamantylamine CAS 768-94-5, Remacemide hydrochloride CAS 111686-79-4, Felbamate CAS 25451-15-4 and Eliprodil CAS 119431-25-3.
NMDAε2 inhibitors constitute a distinctive chemical class recognized for their capacity to modulate the activity of the N-methyl-D-aspartate receptor subtype ε2 (NMDAε2). These inhibitors exert their influence by interfering with the interactions involving NMDAε2, a specialized subunit of the NMDA receptor complex found in certain neural circuits within the brain. The NMDA receptor plays a pivotal role in mediating synaptic plasticity, learning, and memory processes by controlling the flow of calcium ions into neurons. NMDAε2 inhibitors are carefully designed to target specific binding sites or molecular pathways associated with the NMDAε2 subunit, thus influencing its cellular functions and downstream effects.
The development of NMDAε2 inhibitors entails a comprehensive understanding of the structural characteristics of the NMDAε2 subunit and its interactions with other subunits within the NMDA receptor complex. Researchers in this field endeavor to engineer molecules with high selectivity and affinity for NMDAε2, enabling precise modulation of its activities. These inhibitors often incorporate innovative design strategies that disrupt key molecular interactions crucial for NMDAε2's functional role. By gaining insights into the intricate mechanisms through which NMDAε2 participates in neural communication and synaptic plasticity, researchers aim to unravel its significance in fundamental brain processes. The ongoing advancements in molecular pharmacology and chemical synthesis drive the refinement of NMDAε2 inhibitors, promising applications across diverse scientific domains where the manipulation of NMDAε2-mediated processes is of interest.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ro 8-4304 Hydrochloride | 1312991-77-7 | sc-204241 sc-204241A | 10 mg 50 mg | $149.00 $630.00 | ||
Ro 8-4304 Hydrochloride is a potent NMDA epsilon 2 receptor modulator, exhibiting unique binding affinity that influences synaptic plasticity. Its structural conformation allows for specific interactions with receptor sites, facilitating distinct signaling pathways. The compound's reactivity profile is characterized by rapid kinetics, enabling swift modulation of neurotransmitter activity. Additionally, its solubility in polar solvents enhances its accessibility for various biochemical assays, making it a versatile tool in research. | ||||||
PMPA (NMDA antagonist) | 113919-36-1 | sc-204850 sc-204850A | 10 mg 50 mg | $205.00 $849.00 | 2 | |
PMPA is a selective NMDA epsilon 2 antagonist that demonstrates a unique ability to disrupt calcium ion influx through its specific receptor interactions. This compound exhibits a distinctive binding mechanism that alters conformational dynamics of the NMDA receptor, influencing downstream signaling cascades. Its kinetic properties allow for a rapid onset of action, while its stability in various environments enhances its utility in experimental settings, providing insights into synaptic function and neurophysiology. | ||||||
(R)-CPP | 126453-07-4 | sc-202308 sc-202308A | 1 mg 10 mg | $50.00 $325.00 | 1 | |
(R)-CPP is a potent NMDA epsilon 2 receptor modulator, characterized by its ability to selectively inhibit receptor-mediated ion flow. Its unique stereochemistry facilitates specific interactions with the receptor's binding site, leading to altered receptor conformation and modulation of synaptic transmission. The compound exhibits distinct kinetic profiles, allowing for precise timing in experimental applications, and its robust stability across diverse conditions makes it a valuable tool for exploring neurobiological mechanisms. | ||||||
Ro 25-6981 maleate | 1312991-76-6 | sc-204887 sc-204887A sc-204887B | 1 mg 10 mg 50 mg | $107.00 $227.00 $930.00 | ||
Ro 25-6981 maleate is a selective antagonist of the NMDA epsilon 2 receptor, distinguished by its high affinity for the receptor's allosteric site. This compound engages in unique molecular interactions that stabilize the receptor in an inactive conformation, effectively blocking calcium ion influx. Its kinetic behavior reveals rapid binding and unbinding rates, enabling nuanced modulation of synaptic activity. Additionally, its solubility properties enhance its versatility in various experimental environments. | ||||||
Co 101244 hydrochloride | 193359-26-1 | sc-203899 sc-203899A | 10 mg 50 mg | $155.00 $660.00 | 1 | |
Co 101244 hydrochloride acts as a selective modulator of the NMDA epsilon 2 receptor, characterized by its ability to disrupt specific protein-protein interactions within the receptor complex. This compound exhibits unique binding kinetics, allowing for a dynamic equilibrium that influences receptor conformation. Its distinct solubility profile facilitates interactions with lipid membranes, potentially altering membrane fluidity and impacting downstream signaling pathways. | ||||||
4-PPBP maleate | 207572-62-1 | sc-203780 sc-203780A | 10 mg 50 mg | $119.00 $450.00 | ||
4-PPBP maleate functions as a selective modulator of the NMDA epsilon 2 receptor, distinguished by its capacity to engage in unique allosteric interactions that stabilize specific receptor conformations. This compound demonstrates a remarkable affinity for the receptor's binding site, leading to altered ion channel dynamics. Its physicochemical properties enhance its ability to penetrate cellular membranes, potentially influencing intracellular calcium signaling and synaptic plasticity. | ||||||
TCS 46b | 302799-86-6 | sc-204328 sc-204328A | 10 mg 50 mg | $149.00 $630.00 | ||
TCS 46b acts as a selective modulator of the NMDA epsilon 2 receptor, characterized by its ability to induce conformational changes that enhance receptor sensitivity. This compound exhibits unique binding kinetics, allowing for prolonged receptor activation. Its distinct molecular interactions facilitate the formation of stable complexes, influencing downstream signaling pathways. Additionally, TCS 46b's solubility profile aids in its distribution within biological systems, impacting overall receptor functionality. | ||||||
Threo Ifenprodil hemitartrate | 1312991-83-5 | sc-361381 sc-361381A | 10 mg 50 mg | $159.00 $665.00 | ||
Threo Ifenprodil hemitartrate selectively targets the NMDA epsilon 2 receptor, exhibiting a unique affinity that alters receptor dynamics. Its interaction profile promotes specific allosteric modulation, enhancing the receptor's response to endogenous ligands. The compound's kinetic behavior reveals a slow dissociation rate, contributing to sustained receptor engagement. Furthermore, its physicochemical properties, including solubility and stability, play a crucial role in modulating receptor activity and influencing cellular signaling cascades. | ||||||
Eliprodil | 119431-25-3 | sc-203939 sc-203939A | 10 mg 50 mg | $145.00 $510.00 | ||
Eliprodil acts as a selective antagonist at the NMDA epsilon 2 receptor, demonstrating a distinctive binding mechanism that stabilizes the receptor in an inactive conformation. This compound exhibits unique interaction dynamics, characterized by a rapid association rate and prolonged occupancy, which effectively dampens excitatory neurotransmission. Its structural attributes facilitate specific conformational changes, influencing downstream signaling pathways and cellular excitability. | ||||||
TCN 201 | 852918-02-6 | sc-361373 sc-361373A | 10 mg 50 mg | $175.00 $739.00 | ||
TCN 201 functions as a selective modulator of the NMDA epsilon 2 receptor, exhibiting a unique interaction profile that enhances receptor desensitization. Its binding promotes a distinct conformational shift, altering ion channel permeability and influencing calcium influx. The compound's kinetic properties reveal a slow dissociation rate, allowing for sustained receptor inhibition. This behavior impacts synaptic plasticity and neuronal signaling, highlighting its role in modulating excitatory pathways. | ||||||