(R)-CPP CAS: 126453-07-4
MF: C8H17N2O5P
MW: 252.2
A piperazine derivative demonstrating highly potent NMDA receptor antagonism.

(R)-CPP (CAS 126453-07-4)

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Synonym: 3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Application: A piperazine derivative demonstrating highly potent NMDA receptor antagonism
CAS Number: 126453-07-4
Molecular Weight: 252.2
Molecular Formula: C8H17N2O5P
* Refer to Certificate of Analysis for lot specific data (including water content).
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(R)-CPP is a highly potent piperazine-based NMDA receptor antagonist. (R)-CPP is the more active isomer of racemic CPP preparations. (R)-CPP demonstrates selectivity for NMDAε1 receptors with an IC50 value of 41 nM. (R)-CPP is an inhibitor of NMDA ε 1, NMDA ε 2 and NMDA ε 3.


References

1. Davies, J., et al. 1986. Brain Res. 382: 169-173. PMID: 2876749

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (100 mM), and dilute aqueous base.
Storage :
Store at room temperature
Melting Point :
304.03° C (Predicted)
Boiling Point :
546.67° C at 760 mmHg (Predicted)
Density :
1.41 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
Optical Activity :
α20/D -19.8°, c = 1.2 in 2N HCl
IC50 :
Glutamate NMDA receptor: IC50 = 50 nM (rat); Glutamate [NMDA] receptor: IC50 = 86 nM (human); Glutamate receptor ionotropic, AMPA: IC50 = 1.6 µM (rat)
Ki Data :
NMDA ε 1: Ki= 41 nM; Glutamate NMDA receptor; Grin1/Grin2a: Ki= 41 nM (rat); NMDA ε 2: Ki= 0.27 µM; NMDA ε 3: Ki= 0.63 µM; Grin2d: Ki= 1.99 µM
pK Values :
pKa: 1.89 (Predicted), pKb: 9.42 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6603754
MDL Number :
MFCD00153786
SMILES :
C1CN(C[[email protected]@H](N1)C(=O)O)CCCP(=O)(O)O

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Certificate of Analysis

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(R)-CPP  Product Citations

See how others have used (R)-CPP. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28036359  Estep, CM. et al. 2016. PLoS ONE. 11: e0169044.

Citations 1 to 1 of 1 total
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