PMPA (NMDA antagonist) CAS: 113919-36-1
MF: C6H13N2O5P
MW: 224.15
A selective competitive antagonist at the NMDA receptor.

PMPA (NMDA antagonist) (CAS 113919-36-1)

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Application: A selective competitive antagonist at the NMDA receptor
CAS Number: 113919-36-1
Molecular Weight: 224.15
Molecular Formula: C6H13N2O5P
* Refer to Certificate of Analysis for lot specific data (including water content).
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PMPA (NMDA antagonist) is a short-chain competitive NMDA antagonist. PMPA (NMDA antagonist) displays Ki values of 0.84, 2.74, 3.53 and 4.16 μM at NMDAε1, NMDAε2 NMDAε3, and NMDAε4 subunit-containing receptors respectively.


References

1. Harris, N.C., et al. 1992. Brain Res. 594: 176-180. PMID: 1361408
2. Feng, B., et al. 2005. Neuropharmacology. 48: 354-359. PMID: 15721167

Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Store at 4° C
Boiling Point :
524.85° C at 760 mmHg (Predicted)
Density :
1.54 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
Glutamate NMDA receptor: IC50 = 65 nM (rat)
Ki Data :
NR2A: Ki= 0.84 µM; NR2B: Ki= 2.74 µM; NR2C: Ki= 3.53 µM; NR2D: Ki= 4.16 µM
pK Values :
pKa: 0.62 (Predicted), pKb: 9.37 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
17756792
MDL Number :
MFCD08460987
SMILES :
OC(=O)C1NCCN(C1)CP(=O)(O)O

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Certificate of Analysis

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PMPA (NMDA antagonist)  Product Citations

See how others have used PMPA (NMDA antagonist). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 28301262  Nonnekens, J. et al. 2017. Cancer Biother. Radiopharm. 32: 67-73.

PMID: # 27446384  Zhang, Z. et al. 2016. Oncol Lett. 12: 1001-1006.

Citations 1 to 2 of 2 total
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