Molecular structure of PMPA (NMDA antagonist), CAS Number: 113919-36-1
PMPA (NMDA antagonist) (CAS 113919-36-1)
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Application:
PMPA (NMDA antagonist) is a selective competitive antagonist at the NMDA receptor
CAS Number:
113919-36-1
Molecular Weight:
224.15
Molecular Formula:
C6H13N2O5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PMPA (NMDA antagonist) is a short-chain competitive NMDA antagonist. PMPA (NMDA antagonist) displays Ki values of 0.84, 2.74, 3.53 and 4.16 μM at NMDAε1, NMDAε2 NMDAε3, and NMDAε4 subunit-containing receptors respectively.
PMPA (NMDA antagonist) (CAS 113919-36-1) References
- Postinoculation PMPA treatment, but not preinoculation immunomodulatory therapy, protects against development of acute disease induced by the unique simian immunodeficiency virus SIVsmmPBj. | Hodge, S., et al. 1999. J Virol. 73: 8630-9. PMID: 10482616
- Effect of PMPA and PMEA on the kinetics of viral load in simian immunodeficiency virus-infected macaques. | Silvera, P., et al. 2000. AIDS Res Hum Retroviruses. 16: 791-800. PMID: 10826485
- Metabolism of GS-7340, a novel phenyl monophosphoramidate intracellular prodrug of PMPA, in blood. | Eisenberg, EJ., et al. 2001. Nucleosides Nucleotides Nucleic Acids. 20: 1091-8. PMID: 11562963
- Cortically evoked excitatory synaptic transmission in the cat red nucleus is antagonised by D-AP5 but not by D-AP7. | Harris, NC. and Davies, J. 1992. Brain Res. 594: 176-80. PMID: 1361408
- The effect of competitive antagonist chain length on NMDA receptor subunit selectivity. | Feng, B., et al. 2005. Neuropharmacology. 48: 354-9. PMID: 15721167
- Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA). | Rais, R., et al. 2014. J Pharm Biomed Anal. 88: 162-9. PMID: 24055700
- PMPA for nephroprotection in PSMA-targeted radionuclide therapy of prostate cancer. | Kratochwil, C., et al. 2015. J Nucl Med. 56: 293-8. PMID: 25613537
- Glutamate carboxypeptidase II (GCPII) inhibitor 2-PMPA reduces rewarding effects of the synthetic cathinone MDPV in rats: a role for N-acetylaspartylglutamate (NAAG). | Hicks, C., et al. 2017. Psychopharmacology (Berl). 234: 1671-1681. PMID: 28251297
- Identification of 2-PMPA as a novel inhibitor of cytosolic carboxypeptidases. | Wang, R., et al. 2020. Biochem Biophys Res Commun. 533: 1393-1399. PMID: 33092792
- Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs. | Shaw, JP., et al. 1997. Pharm Res. 14: 1824-9. PMID: 9453075
Inhibitor of:
NMDA epsilon 2, and NMDA epsilon 3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PMPA (NMDA antagonist), 10 mg | sc-204850 | 10 mg | $205.00 | |||
PMPA (NMDA antagonist), 50 mg | sc-204850A | 50 mg | $849.00 |