Date published: 2025-11-22

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NMDAε1 Inhibitors

NMDAε1 Inhibitors belong to a distinct chemical class known for their modulation of a crucial neurological receptor called the N-Methyl-D-Aspartate epsilon 1 receptor (NMDAε1). This receptor is part of the NMDA receptor family, which plays a pivotal role in synaptic plasticity and the transmission of excitatory signals in the central nervous system (CNS). NMDA receptors are composed of multiple subunits, and NMDAε1 is a specific subunit variant that has garnered considerable interest due to its involvement in various neurological processes. NMDAε1 Inhibitors are characterized by their ability to bind to the NMDAε1 receptor and modulate its activity. By binding to this receptor, these inhibitors can exert a regulatory influence on synaptic transmission and neuronal excitability. The modulation of NMDAε1 activity is crucial for maintaining the delicate balance between synaptic strengthening and weakening, which underlies learning, memory formation, and overall neural network stability. Chemical compounds falling within the NMDAε1 Inhibitor class often possess unique structural features that enable them to interact selectively with the NMDAε1 subunit. This selectivity is essential to avoid interfering with other NMDA receptor subunits, thereby ensuring precise control over the neural processes mediated by NMDAε1.

Researchers and scientists are actively investigating the pharmacological and physiological implications of NMDAε1 Inhibitors. These compounds have the potential to shed light on the intricate mechanisms governing synaptic plasticity and offer insights into the fundamental processes that shape neural circuits. By understanding the ways in which NMDAε1 Inhibitors interact with the NMDA receptor family, researchers aim to uncover novel strategies for influencing synaptic transmission and neuronal function. This class of inhibitors holds promise as a tool for advancing our understanding of neural network dynamics and may pave the way for future discoveries in the field of neuroscience.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Memantine hydrochloride

41100-52-1sc-203628
50 mg
$68.00
4
(2)

memantine acts as a moderate-level, uncompetitive antagonist of NMDA receptors.

Dextromethorphan

125-71-3sc-278927
sc-278927A
sc-278927B
10 g
100 g
500 g
$174.00
$1133.00
$5106.00
3
(1)

An ingredient commonly found in cough medicines, it can act as an NMDA receptor antagonist at higher doses.

Lamotrigine

84057-84-1sc-201079
sc-201079A
10 mg
50 mg
$118.00
$476.00
1
(1)

Originally developed as an antiepileptic drug, lamotrigine has also been found to have NMDA receptor-blocking properties.

Eliprodil

119431-25-3sc-203939
sc-203939A
10 mg
50 mg
$145.00
$510.00
(1)

NMDA receptor-blocking properties.

CGS 19755

110347-85-8sc-203882
sc-203882A
10 mg
50 mg
$185.00
$781.00
(0)

selfotel was one of the early investigational NMDA receptor antagonists explored for potential neuroprotective effects in stroke.