NKTR Activators
NKTR Activators encompass a variety of chemical compounds that can enhance the functional activity of NKTR. The majority of these compounds, including PMA, Ionomycin, Forskolin, IBMX, U73122, SB216763, and BAPTA-AM, function by directly or indirectly influencing the signaling pathways that NKTR is involved in. They achieve this by either activating or inhibiting specific proteins or enzymes in these pathways, or by modulating critical cellular events such as changes in intracellular calcium or cAMP levels.
On the other hand, the remaining compounds, Calphostin C, Ro-31-8220, BAY 11-7082, and Rapamycin, function by inhibiting key proteins in the pathways that NKTR is involved in. By inhibiting these proteins, they can influence the downstream signaling events, leading to the functional enhancement of NKTR. This shows that NKTR activators can work through several mechanisms to influence the signaling pathways and cellular processes that NKTR is directly involved in, thereby enhancing its functional activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a potent activator of Protein Kinase C (PKC). PKC is a key player in the signaling pathway that is vital for the activation of NKTR. With PKC activation, PMA directly contributes to the functional enhancement of NKTR. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, a critical event for the activation of NKTR. The surge in calcium concentration catalyzed by Ionomycin can directly enhance the functional activity of NKTR. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cAMP levels. This increase triggers the cAMP-dependent signaling pathways in which NKTR is implicated, thereby enhancing functional activity of NKTR. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX inhibits phosphodiesterases, enzymes responsible for the degradation of cAMP. By maintaining high intracellular cAMP levels, IBMX creates an environment that directly enhances the functional activity of NKTR within cAMP-dependent signaling pathways. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a cell-permeable calcium chelator. By modulating intracellular calcium levels, BAPTA-AM influences signaling events that lead to the functional enhancement of NKTR. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $343.00 $1642.00 | 20 | |
Calphostin C is a potent and specific inhibitor of Protein Kinase C (PKC). The inhibition of PKC impacts downstream targets in the PKC pathway, leading to the functional enhancement of NKTR. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
Ro-31-8220 is a potent PKC inhibitor. By hindering PKC, it influences downstream signaling events, leading to the functional enhancement of NKTR. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 inhibits IκB-α phosphorylation, preventing NF-κB activation. This action indirectly leads to the functional enhancement of NKTR in the NF-κB signaling pathway. | ||||||