NKG2-D Activators
The NKG2-D Activators class comprises a diverse set of compounds that can either directly or indirectly modulate the activity of Natural Killer Group 2, member D (NKG2-D), a pivotal receptor involved in immune responses. These activators offer pharmacological strategies for enhancing NKG2-D-mediated cellular responses. Certain compounds within this class, such as Fingolimod, GS-9674, SEW2871, and GW0742, either directly activate NKG2-D signaling or indirectly modulate it through specific receptors like S1P receptors and PPAR-β/δ. These activators initiate downstream signaling cascades associated with NKG2-D activation, providing both direct and indirect means to enhance NKG2-D-mediated cellular responses. The direct activation emphasizes the specificity of these compounds in targeting NKG2-D, offering a focused pharmacological approach for boosting immune responses associated with NKG2-D activation.
Furthermore, activators like S1P, CDDO-Im, LCL161, Clofibrate, Lisofylline, Oltipraz, and CYM5442 modulate NKG2-D signaling either indirectly through pathways such as Nrf2 activation or by influencing the inflammatory milieu. These activators offer diverse mechanisms to enhance NKG2-D-mediated cellular responses, providing pharmacological strategies to boost immune surveillance. The indirect nature of activation highlights the intricate regulatory networks influencing NKG2-D and offers avenues for further exploration of their precise roles in immune modulation. In conclusion, the NKG2-D Activators class presents a valuable toolkit for researchers investigating the augmentation of NKG2-D-mediated immune responses. The diverse mechanisms of activation, both direct and indirect, shed light on the complex regulatory landscape governing NKG2-D signaling. These activators provide a foundation for further investigations into the precise mechanisms by which NKG2-D contributes to immune responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fingolimod | 162359-55-9 | sc-507334 | 10 mg | $160.00 | ||
Fingolimod is a sphingosine-1-phosphate (S1P) receptor modulator that activates NKG2-D signaling indirectly. By binding to S1P receptors, Fingolimod influences downstream signaling pathways associated with NKG2-D activation, providing an indirect means to enhance NKG2-D-mediated cellular responses. | ||||||
SEW2871 | 256414-75-2 | sc-203251 sc-203251A | 5 mg 10 mg | $37.00 $52.00 | 1 | |
SEW2871 is an S1P1 receptor agonist that activates NKG2-D signaling indirectly. By selectively binding to S1P1 receptors, SEW2871 modulates downstream signaling pathways associated with NKG2-D activation, providing an indirect means to enhance NKG2-D-mediated cellular responses. | ||||||
GW 0742 | 317318-84-6 | sc-203991 sc-203991A | 10 mg 50 mg | $190.00 $815.00 | 11 | |
GW0742, a PPAR-β/δ agonist, directly activates NKG2-D signaling. By binding to and activating PPAR-β/δ, GW0742 initiates downstream signaling cascades associated with NKG2-D activation, providing a direct means to enhance NKG2-D-mediated cellular responses. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P, the endogenous ligand for S1P receptors, indirectly activates NKG2-D signaling. By binding to S1P receptors, S1P influences downstream signaling pathways associated with NKG2-D activation, providing an indirect means to enhance NKG2-D-mediated cellular responses. | ||||||
CDDO Imidazolide | 443104-02-7 | sc-504719 | 1 mg | $700.00 | ||
CDDO-Im, an activator of Nrf2, indirectly activates NKG2-D signaling. By activating Nrf2, CDDO-Im modulates downstream signaling pathways associated with NKG2-D activation, providing an indirect means to enhance NKG2-D-mediated cellular responses. | ||||||
LCL-161 | 1005342-46-0 | sc-507541 | 10 mg | $360.00 | ||
LCL161, a SMAC mimetic, indirectly activates NKG2-D signaling. By inhibiting IAP proteins, LCL161 influences downstream signaling pathways associated with NKG2-D activation, providing an indirect means to enhance NKG2-D-mediated cellular responses. | ||||||
Clofibric acid | 882-09-7 | sc-203000 sc-203000A | 10 g 50 g | $24.00 $39.00 | 1 | |
Clofibric acid, a PPAR-α agonist, directly activates NKG2-D signaling. By binding to and activating PPAR-α, Clofibrate initiates downstream signaling cascades associated with NKG2-D activation, providing a direct means to enhance NKG2-D-mediated cellular responses. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz, an Nrf2 activator, indirectly activates NKG2-D signaling. By activating Nrf2, Oltipraz modulates downstream signaling pathways associated with NKG2-D activation, providing an indirect means to enhance NKG2-D-mediated cellular responses. | ||||||
CYM-5442 | 1094042-01-9 | sc-211156 sc-211156A | 5 mg 25 mg | $267.00 $1120.00 | 1 | |
CYM5442 is an S1P4 receptor agonist that activates NKG2-D signaling indirectly. By selectively binding to S1P4 receptors, CYM5442 modulates downstream signaling pathways associated with NKG2-D activation, providing an indirect means to enhance NKG2-D-mediated cellular responses. | ||||||