CYM-5442 (CAS 1094042-01-9)
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CYM-5442 is a selective agonist of the sphingosine-1-phosphate receptor 1 (S1P1), a key regulator in the sphingolipid signaling pathway. This compound has been extensively studied for its role in modulating immune cell trafficking and vascular integrity. By binding to S1P1, CYM-5442 induces receptor internalization and signaling, which in turn affects the migration and distribution of lymphocytes. In research, CYM-5442 has been utilized to investigate the mechanisms of S1P1-mediated signaling pathways, providing insights into the regulation of endothelial barrier function and the dynamics of lymphocyte egress from lymphoid organs. Studies have shown that CYM-5442 can modulate the expression of adhesion molecules and junctional proteins, impacting vascular permeability and leukocyte transendothelial migration. Additionally, CYM-5442 is used to explore the role of S1P1 in angiogenesis and its effects on endothelial cell proliferation, survival, and motility. Research applications also include studying its impact on the immune system, particularly in understanding how S1P1 signaling influences the immune response and inflammation. Overall, CYM-5442 serves as a powerful tool in dissecting the complex biological processes governed by S1P1, contributing significantly to the field of immunology and vascular biology.
CYM-5442 (CAS 1094042-01-9) References
- Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. | Gonzalez-Cabrera, PJ., et al. 2008. Mol Pharmacol. 74: 1308-18. PMID: 18708635
- The spleen responds to intestinal manipulation but does not participate in the inflammatory response in a mouse model of postoperative ileus. | Costes, LM., et al. 2014. PLoS One. 9: e102211. PMID: 25010202
- The S1P1 receptor-selective agonist CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment. | Cheng, Q., et al. 2015. Cell Mol Immunol. 12: 681-91. PMID: 25088224
- Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. | Li, C., et al. 2015. J Neuroinflammation. 12: 70. PMID: 25880547
- Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling. | Marro, BS., et al. 2017. Proc Natl Acad Sci U S A. 114: 3708-3713. PMID: 28325871
- The S1P1 receptor-selective agonist CYM-5442 protects retinal ganglion cells in endothelin-1 induced retinal ganglion cell loss. | Blanco, R., et al. 2017. Exp Eye Res. 164: 37-45. PMID: 28827028
- High-density lipoprotein (HDL) promotes angiogenesis via S1P3-dependent VEGFR2 activation. | Jin, F., et al. 2018. Angiogenesis. 21: 381-394. PMID: 29450744
- Differential Tolerance to FTY720-Induced Antinociception in Acute Thermal and Nerve Injury Mouse Pain Models: Role of Sphingosine-1-Phosphate Receptor Adaptation. | Sim-Selley, LJ., et al. 2018. J Pharmacol Exp Ther. 366: 509-518. PMID: 29945931
- Combination of sphingosine-1-phosphate receptor 1 (S1PR1) agonist and antiviral drug: a potential therapy against pathogenic influenza virus. | Zhao, J., et al. 2019. Sci Rep. 9: 5272. PMID: 30918324
- Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood-brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis. | Zhang, Y., et al. 2022. Fluids Barriers CNS. 19: 57. PMID: 35820896
- Blocking SphK/S1P/S1PR1 axis signaling pathway alleviates remifentanil-induced hyperalgesia in rats. | Li, J., et al. 2023. Neurosci Lett. 801: 137131. PMID: 36801239
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CYM-5442, 5 mg | sc-211156 | 5 mg | $267.00 | |||
CYM-5442, 25 mg | sc-211156A | 25 mg | $1120.00 |