NKG2 Activators
NKG2 Activators denote a range of compounds that can enhance the functionality of NKG2, a protein involved in various cellular processes including immune response and cellular metabolism. These compounds primarily exert their influence by manipulating various biological processes and pathways closely associated with the functional role of NKG2. For instance, PMA, an activator of protein kinase C (PKC), enhances NKG2 function by activating DAP12. Similarly, Ionomycin, a calcium ionophore, heightens intracellular calcium levels, which under certain conditions can enhance NKG2 functionality.
Genistein, a tyrosine kinase inhibitor, and Forskolin, an activator of adenylate cyclase, all play a role in enhancing NKG2 functionality by altering cellular metabolic processes and phosphorylation of associated proteins. H-89, a Protein Kinase A (PKA) inhibitor, and Staurosporine, a non-selective protein kinase inhibitor, both enhance NKG2 functionality through the regulation of phosphorylation of proteins associated with NKG2. Lastly, W7, a calmodulin inhibitor, enhances the functionality of NKG2 by influencing the MAPK pathway.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC can phosphorylate and activate DAP12, a protein associated with NKG2 receptors. Upon activation, DAP12 can enhance the functional activity of NKG2. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. This increase in calcium levels can trigger the activation of calcineurin, which subsequently dephosphorylates NFAT proteins, leading to their nuclear translocation and inhibitory effect on NKG2. However, in the presence of a calcineurin inhibitor such as Cyclosporin A, this pathway can be blocked, and the functional activity of NKG2 can be enhanced. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. Tyrosine kinases can regulate NKG2 through phosphorylation of associated proteins. By inhibiting these kinases, Genistein can enhance the functional activity of NKG2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases intracellular cAMP levels. cAMP can enhance the functional activity of NKG2 by activating PKA, which then phosphorylates and activates proteins associated with NKG2 receptors. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a non-selective protein kinase inhibitor. Protein kinases can regulate NKG2 through phosphorylation of associated proteins. By inhibiting these kinases, Staurosporine can enhance the functional activity of NKG2. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W7 is a calmodulin inhibitor. Calmodulin can regulate NKG2 through control of calcium-mediated signaling processes. By inhibiting calmodulin, W7 can alter these pathways and enhance the functional activity of NKG2. | ||||||