NKG2 Antibody (20D5): sc-53026
- NKG2 Antibody (20D5) is a rat monoclonal IgG2a NKG2 antibody provided at 200 µg/ml
- raised against NKG2 of mouse origin
- NKG2 Antibody (20D5) is recommended for detection of NKG2-A, NKG2-C and NKG2-E of mouse origin by FCM
- Anti-NKG2 Antibody (20D5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NKG2 Antibody (20D5). This work is in progress.
NKG2 Antibody (20D5) is a rat monoclonal IgG2a antibody that detects the NKG2 protein of mouse origin by flow cytometry (FCM). anti-NKG2 antibody (20D5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NKG2 plays a crucial role in the immune response, particularly in the activation of natural killer (NK) cells, which are essential for the body′s defense against tumors and virally infected cells. NKG2 proteins, such as NKG2-D, are expressed on the surface of NK cells, γδ T cells, and CD8+ αβ T cells, and interact with stress-inducible ligands like MICA, which is often overexpressed in various epithelial tumors. This interaction is vital for the recognition and elimination of transformed cells, highlighting NKG2′s importance in tumor immunology. The regulation of NK cell activity through NKG2 and associated receptors underscores the potential of targeting this pathway for therapeutic interventions in cancer and other diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NKG2 Antibody (20D5) References:
- Inhibitory role of murine Ly49 lectin-like receptors on natural killer cells. | Salcedo, M. 1999. Curr Top Microbiol Immunol. 244: 97-105. PMID: 10453652
- The CD94/NKG2 family of receptors: from molecules and cells to clinical relevance. | Borrego, F., et al. 2006. Immunol Res. 35: 263-78. PMID: 17172651
- Pillars Article: Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. 1999. 285: 727-729. | Bauer, S., et al. 2018. J Immunol. 200: 2231-2233. PMID: 29555676
- Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors. | Hayami, K., et al. 1997. J Biol Chem. 272: 7320-7. PMID: 9054430
- Divergent functions of lectin-like receptors on NK cells. | Ryan, JC. and Seaman, WE. 1997. Immunol Rev. 155: 79-89. PMID: 9059884
- Natural killer cell receptors. | Long, EO. and Wagtmann, N. 1997. Curr Opin Immunol. 9: 344-50. PMID: 9203417
- HLA class I specific inhibitory receptors. | Moretta, A. and Moretta, L. 1997. Curr Opin Immunol. 9: 694-701. PMID: 9368779
- Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. | Vance, RE., et al. 1997. Eur J Immunol. 27: 3236-41. PMID: 9464811
- The major SHP-1-binding, tyrosine-phosphorylated protein in macrophages is a member of the KIR/LIR family and an SHP-1 substrate. | Berg, KL., et al. 1998. Oncogene. 17: 2535-41. PMID: 9824165
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NKG2 Antibody (20D5) | sc-53026 | 200 µg/ml | $316.00 | |||
NKG2 Antibody (20D5) AC | sc-53026 AC | 500 µg/ml, 25% agarose | $416.00 | |||
NKG2 Antibody (20D5) HRP | sc-53026 HRP | 200 µg/ml | $316.00 | |||
NKG2 Antibody (20D5) FITC | sc-53026 FITC | 200 µg/ml | $330.00 | |||
NKG2 Antibody (20D5) PE | sc-53026 PE | 200 µg/ml | $343.00 | |||
NKG2 Antibody (20D5) Alexa Fluor® 488 | sc-53026 AF488 | 200 µg/ml | $357.00 | |||
NKG2 Antibody (20D5) Alexa Fluor® 546 | sc-53026 AF546 | 200 µg/ml | $357.00 | |||
NKG2 Antibody (20D5) Alexa Fluor® 594 | sc-53026 AF594 | 200 µg/ml | $357.00 | |||
NKG2 Antibody (20D5) Alexa Fluor® 647 | sc-53026 AF647 | 200 µg/ml | $357.00 | |||
NKG2 Antibody (20D5) Alexa Fluor® 680 | sc-53026 AF680 | 200 µg/ml | $357.00 | |||
NKG2 Antibody (20D5) Alexa Fluor® 790 | sc-53026 AF790 | 200 µg/ml | $357.00 |