NICE-1 Inhibitors
NICE-1 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the Nicotinamide Nucleotide Adenylyltransferase 1 (NAT1) enzyme. NAT1 plays a critical role in cellular metabolism by catalyzing the transfer of an adenylyl group from ATP to nicotinamide mononucleotide (NMN), a key step in the biosynthesis of NAD+, an essential cofactor involved in various metabolic processes. NICE-1 inhibitors interfere with this enzymatic activity, effectively disrupting the NAD+ biosynthesis pathway. This disruption can have widespread effects on cellular metabolism, energy homeostasis, and redox balance, as NAD+ is integral to numerous enzymatic reactions, particularly those involved in cellular respiration and oxidative stress response.
Structurally, NICE-1 inhibitors are designed to bind to the active site of NAT1 with high specificity, preventing its interaction with NMN. They often feature motifs that mimic the natural substrate of the enzyme or bind to allosteric sites, leading to conformational changes that reduce enzymatic efficiency. This class of inhibitors can vary in their chemical makeup, but many of them contain heterocyclic structures or other moieties that enhance their binding affinity and stability within the enzyme pocket. The ability of NICE-1 inhibitors to selectively target NAT1 makes them valuable tools for research into NAD+ metabolism, offering insights into the complex regulation of metabolic pathways at the cellular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GDC-0941 | 957054-30-7 | sc-364498 sc-364498A | 5 mg 10 mg | $184.00 $195.00 | 2 | |
PI3K inhibitor disrupting the PI3K/Akt pathway. GDC-0941 interferes with intracellular signaling, potentially modulating NICE-1 indirectly. The PI3K/Akt pathway is integral in cell survival and proliferation, and alterations induced by GDC-0941 may impact the expression or activity of NICE-1 through intricate signaling networks. | ||||||
AZD5363 | 1143532-39-1 | sc-503190 | 5 mg | $309.00 | ||
AKT inhibitor targeting the PI3K/Akt pathway. AZD5363 interferes with Akt signaling, potentially modulating NICE-1 indirectly. The PI3K/Akt pathway is crucial in cellular processes, and alterations induced by AZD5363 may impact the expression or activity of NICE-1 through complex signaling networks. | ||||||
BAY 80-6946 | 1032568-63-0 | sc-503264 | 5 mg | $551.00 | ||
PI3K inhibitor affecting the PI3K/Akt pathway. BAY 80-6946 interferes with intracellular signaling, potentially modulating NICE-1 indirectly. The PI3K/Akt pathway plays a pivotal role in cell survival and proliferation, and alterations induced by BAY 80-6946 may impact the expression or activity of NICE-1 through intricate signaling networks. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor affecting the mTOR pathway. Rapamycin interferes with mTOR signaling, potentially modulating NICE-1 indirectly. The mTOR pathway is vital in cell growth and metabolism, and alterations induced by Rapamycin may impact the expression or activity of NICE-1 through intricate signaling networks. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $178.00 $325.00 | 67 | |
AKT inhibitor targeting the PI3K/Akt pathway. MK-2206 interferes with Akt signaling, potentially modulating NICE-1 indirectly. The PI3K/Akt pathway is integral in cellular processes, and alterations induced by MK-2206 may impact the expression or activity of NICE-1 through complex signaling networks. | ||||||
BKM120 | 944396-07-0 | sc-364437 sc-364437A sc-364437B sc-364437C | 5 mg 10 mg 25 mg 50 mg | $173.00 $230.00 $275.00 $332.00 | 9 | |
PI3K inhibitor disrupting the PI3K/Akt pathway. BKM120 interferes with intracellular signaling, potentially modulating NICE-1 indirectly. The PI3K/Akt pathway is crucial in cell survival and proliferation, and alterations induced by BKM120 may impact the expression or activity of NICE-1 through intricate signaling networks. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor disrupting the PI3K/Akt pathway. LY294002 interferes with intracellular signaling, potentially modulating NICE-1 indirectly. The PI3K/Akt pathway plays a pivotal role in cellular processes, and alterations induced by LY294002 may impact the expression or activity of NICE-1 through intricate signaling networks. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $128.00 $638.00 | 7 | |
mTOR inhibitor affecting the mTOR pathway. Everolimus interferes with mTOR signaling, potentially modulating NICE-1 indirectly. The mTOR pathway is vital in cell growth and metabolism, and alterations induced by Everolimus may impact the expression or activity of NICE-1 through intricate signaling networks. | ||||||
GSK2126458 | 1086062-66-9 | sc-364503 sc-364503A | 2 mg 10 mg | $260.00 $1029.00 | ||
PI3K/mTOR dual inhibitor disrupting the PI3K/Akt/mTOR pathway. GSK2126458 interferes with intracellular signaling, potentially modulating NICE-1 indirectly. The PI3K/Akt/mTOR pathway is integral in cell survival and proliferation, and alterations induced by GSK2126458 may impact the expression or activity of NICE-1 through intricate signaling networks. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $207.00 | 8 | |
PI3K/mTOR dual inhibitor targeting the PI3K/Akt/mTOR pathway. BEZ235 interferes with intracellular signaling, potentially modulating NICE-1 indirectly. The PI3K/Akt/mTOR pathway is crucial in cell survival and proliferation, and alterations induced by BEZ235 may impact the expression or activity of NICE-1 through intricate signaling networks. | ||||||