NGL-1 Activators
NGL-1 activators belong to a specialized class of chemical compounds that interact with the neurotrophin receptor known as TrkA, which is the high-affinity receptor for nerve growth factor (NGF). NGF is a neurotrophic factor critical for the survival and maintenance of sympathetic and sensory neurons during development and throughout adulthood. The NGL-1 activators are designed to engage with this receptor, modulating its activity. The interaction between NGL-1 activators and the TrkA receptor is a subject of extensive research, due to the pivotal role of TrkA in the complex signaling pathways that influence the development and function of certain types of nerve cells. These activators are typically small molecules that can cross cell membranes and are structured to specifically target the TrkA receptor with high affinity.
The mechanism of action of NGL-1 activators is based on their ability to bind to the TrkA receptor and induce a conformational change that leads to the activation of its intrinsic tyrosine kinase activity. Once activated, the receptor autophosphorylates on specific tyrosine residues within its intracellular domain. This phosphorylation event initiates a cascade of intracellular signaling pathways involving various intermediates such as PI3 kinase, PLC-gamma, and the MAPK/ERK pathway. These signaling pathways ultimately influence cellular processes such as survival, differentiation, and growth.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
A selective inhibitor of phosphodiesterase 4 (PDE4), which increases intracellular cAMP levels, potentially leading to PKA activation and subsequent modulation of gene expression, including genes related to neuronal development and synapse formation, where NGL-1 is implicated. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Directly stimulates adenylate cyclase, elevating cAMP levels, which can enhance PKA activity. This cascade may influence transcription factors and the expression of synaptic proteins such as NGL-1. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that increases intracellular calcium levels, which may influence calcium/calmodulin-dependent protein kinase (CaMK) pathways, potentially affecting synaptic protein expression including NGL-1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
An activator of protein kinase C (PKC) which can regulate a wide range of cellular functions including gene expression. PKC activation can lead to changes in the expression of proteins involved in synaptogenesis, potentially affecting NGL-1. | ||||||
Kainic acid monohydrate | 58002-62-3 | sc-269283 | 10 mg | $270.00 | ||
An agonist of glutamate receptors which can induce synaptic activity and potentially stimulate the expression of synaptic proteins, including NGL-1, through activation of CaMK and other signaling pathways. | ||||||
Calcium dibutyryladenosine cyclophosphate | 362-74-3 | sc-482205 | 25 mg | $147.00 | ||
A cAMP analog that can penetrate cell membranes and resist degradation, potentially leading to PKA activation and influence on gene expression, which may include genes related to NGL-1 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Affects gene transcription by activating nuclear retinoic acid receptors. In the nervous system, it has been known to influence the expression of a range of genes involved in neural development and could potentially affect NGL-1 expression. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $40.00 $70.00 $110.00 $350.00 | 15 | |
While it is an amino acid, in the central nervous system, glycine acts as an inhibitory neurotransmitter and can also modulate neuronal activity and thus potentially influence the expression of synaptic proteins including NGL-1. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3, leading to altered signaling pathways that can impact gene expression related to neuronal development and synaptic plasticity, where NGL-1 is potentially involved. | ||||||
(S)-3,5-DHPG | 162870-29-3 | sc-204256 sc-204256A | 5 mg 10 mg | $206.00 $346.00 | 2 | |
A potent and selective agonist for group I metabotropic glutamate receptors which can modulate neuronal excitability and synaptic plasticity, potentially affecting the expression of synaptic proteins, including NGL-1. | ||||||