NF kappa B Activators
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $66.00 $278.00 | 6 | |
Imiquimod is a potent immunomodulator that engages the NF-kappa B signaling pathway, leading to the activation of various pro-inflammatory cytokines. Its unique structure allows for specific interactions with cellular receptors, promoting the translocation of NF-kappa B to the nucleus. This process enhances gene expression related to immune responses. The compound's ability to modulate signaling cascades highlights its role in influencing cellular behavior and immune system dynamics. | ||||||
C16 Ceramide (N-Palmitoylsphingosine, D-erythro) | 24696-26-2 | sc-201379 sc-201379A | 5 mg 25 mg | $117.00 $479.00 | 5 | |
C16 Ceramide, a sphingolipid, plays a crucial role in cellular signaling by modulating the NF-kappa B pathway. Its unique fatty acid chain facilitates interactions with membrane receptors, influencing lipid raft dynamics and cellular stress responses. By promoting the phosphorylation of IκB proteins, C16 Ceramide enhances the release of NF-kappa B dimers, leading to their nuclear translocation. This process is vital for regulating gene expression involved in inflammation and cell survival. | ||||||
Azelastine HCl | 79307-93-0 | sc-201096 sc-201096A sc-201096B sc-201096C sc-201096D | 100 mg 250 mg 1 g 5 g 10 g | $94.00 $204.00 $655.00 $1989.00 $3264.00 | ||
Azelastine HCl exhibits intriguing interactions with the NF-kappa B signaling pathway, primarily through its ability to disrupt IκB degradation. This compound influences the phosphorylation state of key proteins, altering the dynamics of the cytoplasmic-nuclear translocation of NF-kappa B. Its unique structural features allow for specific binding affinities, modulating downstream gene expression and cellular responses to stress, thereby impacting inflammatory processes at a molecular level. | ||||||
FSL-1 | 322455-70-9 | sc-396677 | 100 µg | $250.00 | 3 | |
FSL-1 is a potent activator of the NF-kappa B pathway, characterized by its ability to engage specific pattern recognition receptors. This interaction triggers a cascade of signaling events, leading to the phosphorylation of IκB proteins and subsequent release of NF-kappa B dimers. The compound's unique structural motifs facilitate robust binding to receptor sites, enhancing the kinetics of downstream signaling and influencing transcriptional regulation in response to cellular stimuli. | ||||||
(R)-FSL-1 | sc-396679 | 100 µg | $370.00 | |||
(R)-FSL-1 is a selective modulator of the NF-kappa B signaling pathway, distinguished by its affinity for Toll-like receptors. This compound initiates a series of molecular interactions that promote the degradation of IκB, allowing NF-kappa B to translocate to the nucleus. Its unique stereochemistry enhances receptor binding, optimizing the activation kinetics and amplifying the transcriptional response to various stimuli, thereby influencing cellular homeostasis. | ||||||
Doxifluridine | 3094-09-5 | sc-211379 | 100 mg | $169.00 | 2 | |
Doxifluridine acts as a potent modulator of the NF-kappa B pathway, characterized by its ability to disrupt the IκB-NF-kappa B complex. This compound engages in specific interactions with kinases, facilitating the phosphorylation of IκB proteins. The resulting degradation of IκB leads to the release and nuclear translocation of NF-kappa B dimers. Its unique structural features enhance binding affinity, influencing downstream gene expression and cellular signaling dynamics. | ||||||