Molecular structure of Azelastine HCl, CAS Number: 79307-93-0
Azelastine HCl (CAS 79307-93-0)
Application:
Azelastine HCl is an H1-receptor antagonist with antiallergic effects and disrupts TNF alpha activity
CAS Number:
79307-93-0
Purity:
98%
Molecular Weight:
418.40
Molecular Formula:
C22H24ClN3O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
Azelastine HCl is an H1-receptor antagonist, with antiallergic effects related to histamine antagonism, and further antiallergic and antiinflammatory effects unrelated to H1-receptor binding. Azelastine is shown to block secretion of IL-6, IL-8, and TNF-alpha from mast cells by inhibiting NF-kappaB activation.
Azelastine HCl (CAS 79307-93-0) References
- Azelastine nasal spray: a review of pharmacology and clinical efficacy in allergic and nonallergic rhinitis. | Lieberman, PL. and Settipane, RA. 2003. Allergy Asthma Proc. 24: 95-105. PMID: 12776442
- Azelastine inhibits secretion of IL-6, TNF-alpha and IL-8 as well as NF-kappaB activation and intracellular calcium ion levels in normal human mast cells. | Kempuraj, D., et al. 2003. Int Arch Allergy Immunol. 132: 231-9. PMID: 14646384
- Comparative study of sensory attributes of two antihistamine nasal sprays: olopatadine 0.6% and azelastine 0.1%. | Meltzer, EO., et al. 2008. Allergy Asthma Proc. 29: 659-68. PMID: 19144261
- Long-term multicentric study with azelastine in patients with intrinsic asthma. | Ulbrich, E. and Nowak, H. 1990. Arzneimittelforschung. 40: 1225-30. PMID: 2085334
- Stability study of the antihistamine drug azelastine HCl along with a kinetic investigation and the identification of new degradation products. | El-Shaheny, RN. and Yamada, K. 2014. Anal Sci. 30: 691-7. PMID: 24919676
- Cinnamaldehyde is an effective anti-inflammatory agent for treatment of allergic rhinitis in a rat model. | Hancı, D., et al. 2016. Int J Pediatr Otorhinolaryngol. 84: 81-7. PMID: 27063758
- Validated sensitive spectrofluorimetric method for determination of antihistaminic drug azelastine HCl in pure form and in pharmaceutical dosage forms: application to stability study. | El-Masry, AA., et al. 2017. Luminescence. 32: 177-181. PMID: 27279096
- A review of the clinical efficacy and safety of MP-AzeFlu, a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate, in clinical studies conducted during different allergy seasons in the US. | Prenner, BM. 2016. J Asthma Allergy. 9: 135-43. PMID: 27468241
- Green Analytical Methods for the Separation of Seven Antihistamines: Application in Separation of Azelastine and Related Impurities in Nasal Solution. | da Costa, LM., et al. 2019. Int J Anal Chem. 2019: 9489723. PMID: 30886632
- Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs. | Chand, N., et al. 1986. Allergy. 41: 473-8. PMID: 3098130
- A Novel Approach of Drug Localization through Development of Polymeric Micellar System Containing Azelastine HCl for Ocular Delivery. | Devi, S., et al. 2019. Pharm Nanotechnol. 7: 314-327. PMID: 31362666
- [The problem of recurrence of rhino-sinusal polyposis: pilot trial with locally administered azelastine HCL in the prevention of relapses]. | Bussi, M., et al. 1995. Acta Otorhinolaryngol Ital. 15: 101-6. PMID: 8928647
- The effect of antiallergic intranasal formulations on ciliary beat frequency of human nasal epithelium in vitro. | Alberty, J. and Stoll, W. 1998. Allergy. 53: 986-9. PMID: 9821480
Inhibitor of:
Histamine H1 Receptor.Activator of:
NF kappa B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Azelastine HCl, 100 mg | sc-201096 | 100 mg | $94.00 | |||
Azelastine HCl, 250 mg | sc-201096A | 250 mg | $204.00 | |||
Azelastine HCl, 1 g | sc-201096B | 1 g | $655.00 | |||
Azelastine HCl, 5 g | sc-201096C | 5 g | $1989.00 | |||
Azelastine HCl, 10 g | sc-201096D | 10 g | $3264.00 |