FSL-1 (CAS 322455-70-9)
See product citations (3)
Alternate Names:
Fibroblast-stimulating Lipopeptide
Application:
FSL-1 is a synthetic lipoprotein
CAS Number:
322455-70-9
Molecular Weight:
1666.15
Molecular Formula:
C84H140N14O18S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein that represents the N-terminal part of the 44kDa lipoprotein LP44 of Mycoplasma salivarium. It is also a stimulator of TLR2/TLR6, an inducer of TNF-alpha production in macrophages, upregulator proinflammatory cytokines, and an activator of the proinflammatory transcription factor NF-kappaB. FSL-1 also referred to as a synthetic lipoprotein particle(SLP), is an artificial lipoprotein designed to mimic the structure and function of lipoproteins found in the human body. Comprising a phospholipid bilayer and a cholesterol ester, FSL-1 serves as useful in scientific investigations focused on understanding lipoproteins.
FSL-1 (CAS 322455-70-9) References
- Signaling pathways induced by lipoproteins derived from Mycoplasma salivarium and a synthetic lipopeptide (FSL-1) in normal human gingival fibroblasts. | Nakamura, J., et al. 2002. Microbiol Immunol. 46: 151-8. PMID: 12008923
- Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1. | Hübschle, T., et al. 2006. Am J Physiol Regul Integr Comp Physiol. 290: R180-7. PMID: 16154916
- The diacylated lipopeptide FSL-1 induces TLR2-mediated Th2 responses. | Kiura, K., et al. 2006. FEMS Immunol Med Microbiol. 48: 44-55. PMID: 16965351
- FSL-1, a bacterial-derived toll-like receptor 2/6 agonist, enhances resistance to experimental HSV-2 infection. | Rose, WA., et al. 2009. Virol J. 6: 195. PMID: 19903337
- The Toll-like receptor 2 (TLR2) ligand FSL-1 is internalized via the clathrin-dependent endocytic pathway triggered by CD14 and CD36 but not by TLR2. | Shamsul, HM., et al. 2010. Immunology. 130: 262-72. PMID: 20113368
- Multiple Signaling Molecules are Involved in Expression of CCL2 and IL-1β in Response to FSL-1, a Toll-Like Receptor 6 Agonist, in Macrophages. | Won, K., et al. 2012. Korean J Physiol Pharmacol. 16: 447-53. PMID: 23271927
- FSL-1 induces MMP-9 production through TLR-2 and NF-κB /AP-1 signaling pathways in monocytic THP-1 cells. | Ahmad, R., et al. 2014. Cell Physiol Biochem. 34: 929-42. PMID: 25200491
- The role of oxidation in FSL-1 induced signaling pathways of an atopic dermatitis model in HaCaT keratinocytes. | Koren Carmi, I., et al. 2015. Adv Exp Med Biol. 849: 1-10. PMID: 25510360
- FSL-1, a Toll-like Receptor 2/6 Agonist, Induces Expression of Interleukin-1α in the Presence of 27-hydroxycholesterol. | Heo, W., et al. 2014. Korean J Physiol Pharmacol. 18: 475-80. PMID: 25598661
- Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils. | Conejeros, I., et al. 2015. Dev Comp Immunol. 52: 215-25. PMID: 26026246
- The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome. | Kurkjian, CJ., et al. 2017. Sci Rep. 7: 17355. PMID: 29230065
- Semisynthetic, self-adjuvanting vaccine development: Efficient, site-specific sortase A-mediated conjugation of Toll-like receptor 2 ligand FSL-1 to recombinant protein antigens under native conditions and application to a model group A streptococcal vaccine. | Xu, Z., et al. 2020. J Control Release. 317: 96-108. PMID: 31758971
- Design of a MUC1-based tricomponent vaccine adjuvanted with FSL-1 for cancer immunotherapy. | Li, M., et al. 2019. Medchemcomm. 10: 2073-2077. PMID: 32133105
- Human Amnion Epithelial Cells (AECs) Respond to the FSL-1 Lipopeptide by Engaging the NLRP7 Inflammasome. | Lavergne, M., et al. 2020. Front Immunol. 11: 1645. PMID: 32849565
Activator of:
MDL-1, NF kappa B, TLR, TLR2, and TLR6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FSL-1, 100 µg | sc-396677 | 100 µg | $255.00 |