Molecular structure of Doxifluridine, CAS Number: 3094-09-5
Doxifluridine (CAS 3094-09-5)
See product citations (2)
Alternate Names:
Furtulon, Flutron, doxyfluridine, Doxifluridina, Doxifluridinum 5′-Doxifluridine, 5′dFUrd, 5-fluoro-5′-deoxyuridine
Application:
Doxifluridine is a fluorinated pyrimidine with cytostatic activity
CAS Number:
3094-09-5
Purity:
≥99%
Molecular Weight:
246.19
Molecular Formula:
C9H11FN2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Doxifluridine is a fluorinated pyrimidine nucleoside, which displays cytostatic activity. It is known that this compound is the inactive form of 5-Fluorouridine (sc-221027), which is converted by enzymes in vivo . Studies indicate that 5-Fluorouridine causes apoptosis in HCT-116 colorectal carcinoma cells and along with cDNA microarray is a useful tool in studying the expression of 1,200 genes during apoptosis. It is believed that 5-Fluorouridine induces cytotoxicity in cells not only by inhibition of RNA synthesis and processing, but through other unknown mechanisms as well.
Doxifluridine (CAS 3094-09-5) References
- Pyrimidine nucleoside phosphorylase and dihydropyrimidine dehydrogenase indicate chemosensitivity of human colon cancer specimens to doxifluridine and 5-fluorouracil, respectively. | Kobayashi, N., et al. 1999. J Infect Chemother. 5: 144-148. PMID: 11810506
- Probable metabolic interaction of doxifluridine with phenytoin. | Konishi, H., et al. 2002. Ann Pharmacother. 36: 831-4. PMID: 11978162
- Subconjunctival doxifluridine administration suppresses rat choroidal neovascularization through activated thymidine phosphorylase. | Yanagi, Y., et al. 2003. Invest Ophthalmol Vis Sci. 44: 751-4. PMID: 12556409
- Depression of phenytoin metabolic capacity by 5-fluorouracil and doxifluridine in rats. | Konishi, H., et al. 2003. J Pharm Pharmacol. 55: 143-9. PMID: 12625878
- Diverse gene expression pattern during 5-fluorouridine-induced apoptosis. | Schmittgen, TD., et al. 2005. Int J Oncol. 27: 297-306. PMID: 16010409
- Simultaneous determination of doxifluridine and 5-fluorouracil in monkey serum by high performance liquid chromatography with tandem mass spectrometry. | Woo, YA., et al. 2008. J Chromatogr B Analyt Technol Biomed Life Sci. 875: 487-92. PMID: 18945647
- Comparison of average, scaled average, and population bioequivalence methods for assessment of highly variable drugs: an experience with doxifluridine in beagle dogs. | Baek, IH., et al. 2010. Eur J Pharm Sci. 39: 175-80. PMID: 19961933
- Pharmacokinetic analysis of doxifluridine and its metabolites, 5-fluorouracil and 5-fluorouridine, after oral administration in beagle dogs. | Baek, IH., et al. 2013. Eur J Drug Metab Pharmacokinet. 38: 295-9. PMID: 23564503
- Effect of the fluoropyrimidines 5-fluorouracil and doxifluridine on cellular uptake of thiamin. | Heier, MS. and Dornish, JM. 1989. Anticancer Res. 9: 1073-7. PMID: 2530931
- Doxifluridine-conjugated 2-5A analog shows strong RNase L activation ability and tumor suppressive effect. | Kitamura, Y., et al. 2016. Bioorg Med Chem. 24: 3870-4. PMID: 27364610
- Human urinary excretion of doxifluridine and metabolites during a 5-day chemotherapeutic schedule using fluorine-19 nuclear magnetic resonance spectrometry. | Malet-Martino, MC., et al. 1987. Invest New Drugs. 5: 273-9. PMID: 2959633
- Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat. | Berne, M., et al. 1988. Cancer Invest. 6: 377-83. PMID: 2972339
- Differential effects of acyclothymidine, a potent pyrimidine nucleoside phosphorylase inhibitor, on the pharmacokinetics of doxifluridine in rabbits via oral administration. | Hamada, A., et al. 1993. Biol Pharm Bull. 16: 1297-300. PMID: 8130783
- Solid-phase extraction of fluoropyrimidine derivatives on a copper-modified strong cation exchanger: determination of doxifluridine, 5-fluorouracil and its main metabolites in serum by high-performance liquid chromatography with ultraviolet detection. | Guerrieri, A., et al. 1993. J Chromatogr. 617: 71-7. PMID: 8376540
- In vitro toxicity of N3-methyl-5'-deoxy-5-fluorouridine, a novel metabolite of doxifluridine: a bioanalytical investigation. | Zambonin, CG., et al. 1998. J Pharm Biomed Anal. 17: 11-6. PMID: 9608421
Inhibitor of:
Angiogenesis.Activator of:
NF kappa B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Doxifluridine, 100 mg | sc-211379 | 100 mg | $169.00 |