neuroguidin Inhibitors
Neuroguidin inhibitors encompass a variety of chemical compounds that interact with different elements of the cellular signaling pathways, affecting the functional state of neuroguidin indirectly. These inhibitors target kinases, such as CDKs, PI3K, mTOR, MEK, JNK, p38 MAP kinase, and elements of the MAPK/ERK pathway. Through inhibition of these kinases, the compounds can modulate various cellular processes, including phosphorylation events that have a role in regulating protein synthesis and the initiation of translation. Neuroguidin functions in the context of these complex pathways by interacting with eIF4E and other partners involved in the translational machinery. Consequently, the activity of neuroguidin can be influenced by changes in the activity of these pathways.
The chemical classes of these inhibitors range from purine derivatives like Roscovitine, morpholine derivatives like LY294002, macrolides such as Rapamycin, to more diverse structures like the anthrapyrazolone SP600125 and steroidal Wortmannin. These molecules interact with their respective targets to exert an inhibitory effect that ultimately converges on the regulation of translation initiation, a process where neuroguidin is implicated. By doing so, they can indirectly influence the function of neuroguidin, affecting its ability to regulate protein synthesis during the development of the vertebrate nervous system. Although these inhibitors are not directly targeting neuroguidin, their effect on signaling pathways and cellular processes that involve neuroguidin's partners and regulators can lead to changes in neuroguidin activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a purine derivative that inhibits cyclin-dependent kinases (CDKs), which may indirectly affect neuroguidin by altering the phosphorylation state of proteins involved in the initiation of translation, including eIF4E. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 is a morpholine derivative that inhibits phosphoinositide 3-kinases (PI3K), potentially reducing phosphorylation and activation of downstream targets that could modulate the activity of neuroguidin-partner proteins. | ||||||
4E1RCat | 328998-25-0 | sc-361085 sc-361085A | 10 mg 50 mg | $189.00 $797.00 | ||
4E1RCat is a small molecule that directly inhibits eIF4E by blocking its interaction with eIF4G, thereby possibly affecting neuroguidin's role in the eIF4E-mediated translation initiation complex. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a macrolide compound that inhibits mTOR, a kinase involved in translation initiation. Inhibition of mTOR may lead to reduced activity of proteins that interact with neuroguidin, such as eIF4E. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which is part of the MAPK/ERK pathway. By inhibiting this pathway, PD98059 can affect protein synthesis regulation and possibly impact neuroguidin function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which can influence the MAPK/ERK pathway and thus potentially affect proteins that regulate or interact with neuroguidin. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an anthrapyrazolone inhibitor of JNK, which may indirectly influence neuroguidin function by modulating the cellular response to stress, which can affect translation regulation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 is a pyridinyl imidazole compound that inhibits p38 MAP kinase, potentially impacting the signaling pathways that have downstream effects on proteins interacting with neuroguidin. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a steroidal molecule that inhibits PI3K, similar to LY294002, and can thus indirectly affect neuroguidin by modulating the activity of proteins in the PI3K/AKT/mTOR pathway. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
PP242 is a selective mTOR inhibitor that, by reducing mTOR activity, can indirectly affect the function of translation initiation factors and proteins interacting with neuroguidin. | ||||||