neurocalcin Inhibitors
Chemical inhibitors of neurocalcin can affect the protein's function through various mechanisms, primarily centered around the modulation of calcium ion availability and interaction with calmodulin. Calmodulin antagonists like W-7 hydrochloride and phenothiazine derivatives such as Trifluoperazine and Chlorpromazine hydrochloride directly inhibit neurocalcin by competing for calmodulin binding. These chemicals have a higher affinity for calmodulin than neurocalcin, which prevents neurocalcin from associating with calmodulin, thus inhibiting its activity. Without the ability to bind to calmodulin, neurocalcin cannot carry out its calcium-mediated regulatory roles within the cell.
Other chemicals operate by altering intracellular calcium levels, which indirectly affect neurocalcin function. Thapsigargin, by inhibiting the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA), disrupts calcium homeostasis, which reduces the calcium available for neurocalcin to bind. Calcium channel blockers like Verapamil hydrochloride, Nifedipine, Nimodipine, Amlodipine besylate, Bepridil hydrochloride, and Gallopamil hydrochloride limit the influx of calcium ions across the cell membrane, which in turn decreases the intracellular calcium concentration necessary for neurocalcin's activity. Ruthenium Red acts similarly by binding to calcium channels and inhibiting calcium uptake. Dantrolene sodium's inhibition of ryanodine receptors (RyRs) also results in reduced intracellular calcium levels. Consequently, the reduced availability of calcium ions within the cell due to the action of these inhibitors impairs the functional capacity of neurocalcin, since its activation and regulatory functions are contingent on calcium binding.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W-7 hydrochloride is a calmodulin antagonist that competes with neurocalcin for calmodulin binding. The inhibition of neurocalcin is due to the chemical's higher affinity for calmodulin, which prevents neurocalcin from binding to calmodulin and consequently inhibits its function. | ||||||
Trifluoperazine Dihydrochloride | 440-17-5 | sc-201498 sc-201498A | 1 g 5 g | $57.00 $101.00 | 9 | |
Trifluoperazine is a phenothiazine derivative that acts as a calmodulin inhibitor, which can also inhibit neurocalcin by preventing its interaction with calmodulin. Neurocalcin requires calmodulin binding for its activation and function, and by blocking this binding, trifluoperazine inhibits neurocalcin activity. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine hydrochloride is another phenothiazine derivative, known to block calmodulin-dependent processes. It inhibits neurocalcin by restricting its ability to engage with calmodulin, which is critical for neurocalcin's calcium-mediated regulatory functions. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a sesquiterpene lactone that disrupts calcium homeostasis in cells by inhibiting the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA). Since neurocalcin is a calcium-binding protein, the depletion of calcium stores by thapsigargin results in the lack of calcium ions necessary for neurocalcin to function effectively. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker that inhibits the influx of calcium ions. Neurocalcin's functionality depends on internal calcium ion levels; hence, verapamil's action can lead to a functional inhibition of neurocalcin by reducing the calcium ion availability it requires. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red is an ammoniated ruthenium oxychloride complex which binds to calcium channels and inhibits calcium uptake. By preventing calcium ions from entering the cell, Ruthenium Red indirectly inhibits neurocalcin by reducing the intracellular calcium concentration necessary for its activity. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a dihydropyridine calcium channel blocker that impedes calcium ion influx. Neurocalcin needs calcium ions to function, and by inhibiting calcium entry into the cell, nifedipine indirectly inhibits neurocalcin activity due to insufficient calcium ions. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $61.00 $307.00 | 2 | |
Nimodipine is another dihydropyridine calcium channel blocker with a mechanism similar to nifedipine. It inhibits the flow of calcium ions into neurons, thereby indirectly inhibiting neurocalcin by limiting the calcium ions available for its proper function. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $74.00 $166.00 | 2 | |
Amlodipine besylate acts as a calcium channel blocker, specifically inhibiting the L-type calcium channels. This inhibition leads to a decrease in calcium ion concentration within the cell, which is necessary for neurocalcin to bind calcium and perform its functions, thereby inhibiting neurocalcin indirectly. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene sodium inhibits ryanodine receptors (RyRs) on the sarcoplasmic reticulum, which are responsible for the release of calcium ions. By inhibiting these receptors, dantrolene sodium decreases calcium ion levels, leading to an indirect inhibition of neurocalcin, which requires calcium ions for its activity. | ||||||