NET-6 Activators
NET-6 Activators comprise a diverse set of chemical compounds that indirectly increase the functional activity of NET-6 through various signaling pathways. For instance, compounds such as Forskolin and Isoproterenol exert their effects by raising cAMP levels, which in turn activate PKA, a kinase that can phosphorylate and thus enhance the functional role of NET-6 in cellular signaling. Similarly, IBMX, which inhibits the degradation of cAMP, maintains PKA activation level and indirectly sustains NET-6 activity. PMA, as a PKC activator, and calcium ionophores like Ionomycin and A23187, influence NET-6 by modulating the phosphorylation status of proteins within NET-6's signaling network, thereby indirectly promoting its functional activity. This mode of action is pivotal, as PKC and calcium-dependent kinases are integral to the regulation of signaling pathways that NET-6 may be associated with.
In parallel, the activity of NET-6 is also influenced by compounds that modulate phosphoinositide 3-kinases (PI3K) and mitogen-activated protein kinases (MAPKs). The presence of kinase inhibitors like Epigallocatechin Gallate (EGCG) and Genistein can suppresscompetitive signaling, resulting in a more pronounced role for NET-6 within its respective signaling cascade. The action of Genistein, in particular, by inhibiting tyrosine kinases, may alleviate competitive phosphorylation events, thereby facilitating an increase in NET-6's activity. Additionally, sphingosine-1-phosphate, by modulating lipid signaling pathways, can exert a downstream effect that potentiates NET-6 activity by influencing the signaling landscape in which NET-6 operates.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can then phosphorylate substrates that interact with NET-6, enhancing its activity in cell signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which degrade cAMP. By preventing cAMP degradation, IBMX maintains PKA activation and thus sustains the phosphorylation of proteins that may include NET-6 associated proteins, indirectly enhancing NET-6 signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate a myriad of proteins and potentially influence the functional activity of NET-6 by altering its interaction with other cellular proteins. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which could activate calcium-dependent protein kinases that modulate NET-6 activity through phosphorylation of associated proteins. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that leads to increased cAMP and subsequent activation of PKA, which may result in the phosphorylation and activation of NET-6 or its pathway components. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a kinase inhibitor that may suppress competitive signaling pathways, thereby potentiating the function of NET-6 in its respective signaling pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium, activating calcium-dependent kinases that may interact with NET-6, thus enhancing its activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that may reduce phosphorylation competition, allowing NET-6 pathways to be more active and enhancing NET-6's functional role in the cell. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate modulates lipid signaling pathways, which can have a downstream effect of enhancing the signaling functions of NET-6 within these pathways. | ||||||