nephrocystin-4 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin is a selective inhibitor of myosin II ATPase activity. Since nephrocystin-4 is associated with the actin cytoskeleton, the inhibition of myosin II by Blebbistatin could lead to a disruption of actin-myosin interactions, potentially inhibiting nephrocystin-4's function. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK). MLCK plays a role in the phosphorylation of myosin light chains, which is crucial for actin-myosin interactions. Inhibition of MLCK by ML-7 could disrupt functions linked to nephrocystin-4 and the cytoskeleton. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is an inhibitor of formin-mediated actin assembly. Nephrocystin-4 is known to interact with the actin cytoskeleton, and by inhibiting formin, SMIFH2 could prevent proper actin organization, potentially inhibiting nephrocystin-4's cellular function. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin B binds to monomeric G-actin, preventing its polymerization into F-actin, which is essential for cytoskeletal structure and function. As nephrocystin-4 associates with the cytoskeleton, this disruption could lead to its functional inhibition. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D disrupts actin polymerization by capping the fast-growing end of actin filaments. This leads to a breakdown of the actin cytoskeleton, which could result in the inhibition of nephrocystin-4, as it is known to interact with the cytoskeleton. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A sequesters actin dimers and severs actin filaments, leading to depolymerization of actin filaments. This action can disrupt the cytoskeletal structure and potentially inhibit the function of cytoskeleton-associated proteins like nephrocystin-4. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine is a potent inhibitor of protein kinase C (PKC), which is involved in various cell signaling pathways including those that could affect cytoskeletal dynamics. Inhibition of PKC by chelerythrine could indirectly inhibit nephrocystin-4's function. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
Wiskostatin is an inhibitor of the N-WASP which activates the Arp2/3 complex leading to actin polymerization. By inhibiting N-WASP, Wiskostatin could potentially inhibit the actin dynamics and therefore inhibit nephrocystin-4's associated cellular processes. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments and can lead to abnormal actin polymerization. This stabilization can affect the normal dynamics of actin and potentially disrupt the interactions and functions of nephrocystin-4, which is associated with the cytoskeleton. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization into microtubules, another component of the cytoskeleton. While nephrocystin-4 is more closely associated with actin, disruption of microtubules could indirectly inhibit nephrocystin-4's cytoskeletal role. | ||||||