NEPH2 Activators
NEPH2 activators belong to a class of chemical compounds designed to modulate the activity of NEPH2, also known as Nephrin-Like Protein 2. NEPH2 is a transmembrane protein that plays a crucial role in cell adhesion and the maintenance of the glomerular filtration barrier in the kidneys. The glomerular filtration barrier is essential for filtering blood and stop the leakage of proteins into the urine. NEPH2 is primarily expressed in podocytes, specialized cells in the kidney that contribute to the structure and function of the filtration barrier.
NEPH2 activators are specifically engineered to interact with NEPH2 and potentially influence its role in cell adhesion and barrier maintenance. By targeting NEPH2, these compounds may modulate its interactions with other proteins or molecules involved in the glomerular filtration barrier. Research on NEPH2 activators provides insights into the complex mechanisms of kidney function and the molecular processes that underlie the maintenance of renal filtration. Further investigation is necessary to elucidate the precise mechanisms of action and potential biological consequences associated with NEPH2 activation, offering valuable insights into renal physiology and the regulation of glomerular filtration in the kidneys.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid modulates gene expression during brain development and may upregulate NEPH2 as part of neuronal differentiation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates cAMP signaling, which can modulate synaptic protein expression, including NEPH2. | ||||||
Wnt Agonist | 853220-52-7 | sc-222416 sc-222416A | 5 mg 25 mg | $157.00 $609.00 | 23 | |
Wnt signaling is critical for brain development and synaptogenesis, potentially affecting NEPH2 expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoids can influence neuronal function and may affect NEPH2 expression in the brain. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA can activate protein kinase C, potentially altering synaptic protein expression, including NEPH2. | ||||||
N-Methyl-D-Aspartic acid (NMDA) | 6384-92-5 | sc-200458 sc-200458A | 50 mg 250 mg | $109.00 $369.00 | 2 | |
NMDA receptor activation is crucial for synaptic plasticity and could modulate the expression of related proteins like NEPH2. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium influences neuronal development and may impact NEPH2 expression as part of its signaling effects. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid, by modifying histone acetylation, can alter gene expression patterns, potentially affecting NEPH2. | ||||||