NEGR1 Inhibitors
NEGR1 inhibitors represent a class of compounds designed to target the neural epidermal growth factor-like 1 (NEGR1) protein, which plays a crucial role in various cellular processes. NEGR1 is a transmembrane protein belonging to the immunoglobulin superfamily and is primarily expressed in the nervous system, particularly in the developing and adult brain. Its intricate involvement in cell adhesion, migration, and axon guidance underscores its significance in neural development and synaptic plasticity. NEGR1 has been implicated in modulating the formation and maintenance of neural circuits, suggesting its potential relevance in neurobiological phenomena such as learning and memory.
The inhibitors of NEGR1 are meticulously designed molecules that interfere with the protein's function, often by binding to specific regions of the NEGR1 molecule. By modulating NEGR1 activity, these inhibitors have the potential to influence cellular processes that rely on proper neural connectivity. Research in this field is actively exploring the structural nuances of NEGR1 and its interactions with these inhibitors, aiming to elucidate the precise molecular mechanisms underlying their inhibitory effects.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
This compound is an MEK inhibitor that can interfere with the MAPK/ERK pathway, potentially affecting NEGR1's role in neurite outgrowth. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
It is a PI3K inhibitor that can alter the PI3K/Akt pathway, which is potentially implicated in neurodevelopmental processes in which NEGR1 is involved. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin functions as another PI3K inhibitor, potentially affecting the PI3K/Akt pathway and consequently processes associated with NEGR1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
This compound inhibits p38 MAPK and may indirectly affect NEGR1-related signaling due to the role of p38 MAPK in inflammatory responses and possibly neurodevelopment. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which is part of the MAPK pathway. Through JNK inhibition, it may indirectly affect NEGR1-involved signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
A known mTOR inhibitor, could affect the downstream signaling pathways of NEGR1, as mTOR signaling is important in neuronal development and function. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
By inhibiting the Hedgehog signaling pathway, cyclopamine may indirectly affect NEGR1's role in neural development, as Hedgehog signaling is crucial for many aspects of neurodevelopment. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
This compound specifically inhibits Rac1, a GTPase which is part of cellular signaling pathways that NEGR1 may be involved in, particularly in neural cell adhesion and migration. | ||||||
Casein Kinase I Inhibitor, D4476 | 301836-43-1 | sc-202522 | 1 mg | $97.00 | 6 | |
It acts as a CK1 inhibitor, potentially affecting Wnt signaling and thus could indirectly influence NEGR1's function in neurodevelopmental signaling processes. | ||||||
Kenpaullone | 142273-20-9 | sc-200643 sc-200643A sc-200643B sc-200643C | 1 mg 5 mg 10 mg 25 mg | $60.00 $150.00 $226.00 $495.00 | 1 | |
Kenpaullone is a known inhibitor of GSK-3β, which is implicated in Wnt signaling. This pathway can be involved in neurodevelopmental processes where NEGR1 plays a role. | ||||||