NEEP21 Activators
NEEP21 Activators, as described herein, denote a range of chemicals that can indirectly enhance the functionality of NEEP21, a protein involved in endosomal sorting and receptor recycling. These chemicals primarily exert their influence by manipulating various biological processes and pathways closely associated with the functional role of NEEP21. For instance, ionophore antibiotics like Nigericin alter ion balance in endosomes, influencing endosomal sorting mechanisms where NEEP21 plays an integral part.
Other compounds in this classification, such as Chloroquine, disrupt endosomal acidification, a crucial factor for many endosomal functions, thereby influencing NEEP21's role in these processes. Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinases (PI3K), impacts NEEP21 functionality by affecting intracellular trafficking. Moreover, compounds like Latrunculin A and Manumycin A, which interfere with actin polymerization, microtubule assembly, and Ras farnesyltransferase respectively, can indirectly affect NEEP21's functionality by altering cellular processes closely associated with endosomal sorting and trafficking. Finally, Genistein, known for its inhibitory role in tyrosine kinases, can also influence NEEP21 functionality. By interfering with endocytosis and vesicle trafficking, they can indirectly alter NEEP21's role in these processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nigericin sodium salt | 28643-80-3 | sc-201518A sc-201518 sc-201518B sc-201518C sc-201518D | 1 mg 5 mg 25 mg 1 g 5 g | $45.00 $110.00 $235.00 $6940.00 $26879.00 | 9 | |
Nigericin is another ionophore that alters ion gradients across the endosomal membrane, which can influence the endosomal sorting function of NEEP21. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
U18666A causes accumulation of cholesterol in late endosomes and lysosomes, potentially affecting endosomal sorting and recycling where NEEP21 is involved. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is a weak base that accumulates in acidic endosomes, raising their pH and affecting endosomal functions. Changes in endosomal functions can indirectly influence NEEP21. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphatidylinositol 3-kinases (PI3K), which are involved in intracellular trafficking. By influencing the intracellular traffic, it may indirectly affect NEEP21 function. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A binds to actin, disrupting actin polymerization. As actin is involved in many cellular processes including vesicle trafficking, this compound can indirectly influence NEEP21. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $215.00 $622.00 | 5 | |
Manumycin A is an inhibitor of Ras farnesyltransferase, a key regulator of endosomal sorting and trafficking. By altering these processes, it may indirectly affect NEEP21 function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein inhibits tyrosine kinases, which are involved in many cellular processes, including endocytosis and vesicle trafficking, thereby potentially influencing NEEP21. | ||||||