NEDD4-L Activators
NEDD4-L activators represent a diverse group of chemical compounds that modulate the activity of the E3 ubiquitin ligase NEDD4-L. These activators can be broadly categorized based on their primary mechanisms of action, targeting different signaling pathways and molecular events. One subgroup includes compounds that directly inhibit negative regulators of NEDD4-L. For instance, Pyrvinium pamoate inhibits AMPK, thereby relieving the inhibitory phosphorylation on NEDD4-L and enhancing its ubiquitin ligase activity. Auranofin activates NEDD4-L by inhibiting Keap1, leading to NRF2-mediated transcriptional upregulation of NEDD4-L expression. Piperlongumine influences the Akt/mTOR signaling pathway, inhibiting Akt and indirectly activating NEDD4-L. Another subgroup involves compounds that indirectly activate NEDD4-L by modulating specific cellular pathways. For example, Withaferin A inhibits HIF-1α, relieving the inhibitory phosphorylation on NEDD4-L and promoting its ubiquitin ligase activity. MLN4924 inhibits NAE, leading to increased levels of NEDD4-L and enhanced ubiquitin ligase activity. Celastrol inhibits NF-κB, relieving the inhibitory phosphorylation on NEDD4-L and promoting its ubiquitin ligase activity.
Furthermore, 5-Fluorouracil influences the EGFR/MEK/ERK signaling pathway, inhibiting MEK and indirectly activating NEDD4-L. Rigosertib modulates the PLK1/FOXO3a pathway, stabilizing FOXO3a and transcriptionally upregulating NEDD4-L expression. Sanguinarine inhibits STAT3, relieving the inhibitory effect on NEDD4-L and promoting its ubiquitin ligase activity. Moreover, compounds like BX795, Ganetespib, and Torin 1 influence the AMPK, HSP90/SGK1, and mTORC1 pathways, respectively. BX795 inhibits AMPK, leading to enhanced ubiquitin ligase activity of NEDD4-L. Ganetespib inhibits HSP90, resulting in SGK1 degradation and relieving the inhibitory phosphorylation on NEDD4-L. Torin 1 inhibits mTOR, promoting enhanced ubiquitin ligase activity of NEDD4-L. In summary, NEDD4-L activators encompass a variety of compounds that act through distinct mechanisms, influencing cellular pathways and molecular events to modulate the activity of the E3 ubiquitin ligase NEDD4-L. Understanding the diverse strategies employed by these activators provides valuable insights into potential approaches for regulating NEDD4-L activity in cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pyrvinium Pamoate | 3546-41-6 | sc-476920A sc-476920 | 250 mg 500 mg | $228.00 $422.00 | ||
Pyrvinium pamoate, an approved anthelmintic, activates NEDD4-L through inhibition of the AMPK pathway. By suppressing AMPK activity, pyrvinium pamoate removes the inhibitory phosphorylation on NEDD4-L, leading to enhanced ubiquitin ligase activity and subsequent activation of NEDD4-L. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin, a gold-containing compound, activates NEDD4-L by targeting the Keap1/NRF2 pathway. Through inhibition of Keap1, auranofin stabilizes NRF2, which then transcriptionally upregulates NEDD4-L expression. This indirect activation enhances the levels of NEDD4-L, promoting its ubiquitin ligase activity. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine, a natural alkaloid, activates NEDD4-L by influencing the Akt/mTOR signaling pathway. It inhibits Akt, leading to decreased mTOR phosphorylation. This modulation of Akt/mTOR signaling indirectly activates NEDD4-L by relieving the inhibitory phosphorylation on NEDD4-L and enhancing its ubiquitin ligase activity. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A, a steroidal lactone, activates NEDD4-L by modulating the HIF-1α pathway. Through inhibition of HIF-1α, withaferin A indirectly activates NEDD4-L. Reduced HIF-1α levels relieve the inhibitory phosphorylation on NEDD4-L, promoting its ubiquitin ligase activity and subsequent activation. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol, a natural triterpenoid, activates NEDD4-L by inhibiting the NF-κB signaling pathway. Through suppression of NF-κB, celastrol indirectly activates NEDD4-L by relieving the inhibitory phosphorylation on NEDD4-L. This enhances the ubiquitin ligase activity of NEDD4-L and promotes the ubiquitination of its substrates. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil, an antimetabolite, activates NEDD4-L by influencing the EGFR/MEK/ERK signaling pathway. It inhibits MEK, leading to decreased ERK phosphorylation. This modulation of the EGFR/MEK/ERK pathway indirectly activates NEDD4-L by relieving the inhibitory phosphorylation, promoting its ubiquitin ligase activity and subsequent activation. | ||||||
Sanguinarium | 2447-54-3 | sc-473396 | 10 mg | $220.00 | ||
Sanguinarium, a natural alkaloid, activates NEDD4-L by influencing the STAT3 pathway. It inhibits STAT3, leading to decreased transcription of miR-93. Reduced miR-93 levels relieve the inhibitory effect on NEDD4-L, promoting its ubiquitin ligase activity and subsequent activation. | ||||||
BX 795 | 702675-74-9 | sc-281689 sc-281689A sc-281689C sc-281689B sc-281689D sc-281689E | 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg | $219.00 $273.00 $331.00 $495.00 $882.00 $1489.00 | 5 | |
BX795, an AMPK inhibitor, activates NEDD4-L through modulation of the AMPK signaling pathway. Inhibition of AMPK by BX795 relieves the inhibitory phosphorylation on NEDD4-L, leading to enhanced ubiquitin ligase activity and activation of NEDD4-L. | ||||||
Ganetespib | 888216-25-9 | sc-364496 sc-364496A | 10 mg 250 mg | $273.00 $1040.00 | ||
Ganetespib, an HSP90 inhibitor, activates NEDD4-L by influencing the HSP90/SGK1 pathway. Inhibition of HSP90 by ganetespib leads to degradation of SGK1, relieving the inhibitory phosphorylation on NEDD4-L. This enhances the ubiquitin ligase activity of NEDD4-L and promotes the ubiquitination of its substrates. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin 1, an mTOR inhibitor, activates NEDD4-L by modulating the mTORC1 pathway. Inhibition of mTOR by Torin 1 relieves the inhibitory phosphorylation on NEDD4-L, leading to enhanced ubiquitin ligase activity and activation of NEDD4-L. | ||||||