NDUFS Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin (CAS 657-24-9) is a potent inhibitor of NDUFS, targeting complex I in mitochondrial oxidative phosphorylation, reducing cellular respiration. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $291.00 | 24 | |
Piericidin A functions as a notable inhibitor of the NADH:ubiquinone oxidoreductase (NDUFS) complex within the mitochondrial respiratory chain. Its unique molecular structure allows for specific interactions with the enzyme's active site, effectively disrupting electron transfer processes. This inhibition alters the redox state of the mitochondria, influencing metabolic pathways and energy production. Additionally, Piericidin A exhibits distinct lipophilicity, enhancing its affinity for mitochondrial membranes. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone acts as a potent inhibitor of the NADH:ubiquinone oxidoreductase (NDUFS) complex, effectively blocking electron transport in the mitochondrial respiratory chain. Its unique polycyclic structure facilitates strong binding to the enzyme, preventing substrate access and disrupting normal electron flow. This interaction leads to a significant decrease in ATP synthesis and alters cellular redox balance. Furthermore, Rotenone's lipophilic nature enhances its integration into lipid membranes, impacting mitochondrial function. | ||||||
Myxothiazol | 76706-55-3 | sc-507550 | 1 mg | $148.00 | ||
This compound inhibits complex III of the electron transport chain, indirectly affecting complex I activity, including NDUFS3. | ||||||
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, free base | 28289-54-5 | sc-208657 | 25 mg | $430.00 | 5 | |
While primarily known for its neurotoxic effects, MPTP can interfere with complex I and NDUFS3, contributing to mitochondrial dysfunction in certain contexts. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
An anticancer drug, doxorubicin can lead to mitochondrial dysfunction and impact complex I, including the NDUFS3 subunit. | ||||||
Phenformin Hydrochloride | 834-28-6 | sc-219590 | 10 g | $119.00 | 4 | |
Like metformin, phenformin is another antidiabetic drug that can indirectly modulate NDUFS3 through its effects on AMPK and mitochondrial function. | ||||||