NDUFB2 Inhibitors
NDUFB2 inhibitors belong to a class of chemical compounds that primarily target the NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2 (NDUFB2), a crucial component of the mitochondrial respiratory chain complex I. Mitochondrial complex I plays a pivotal role in the electron transport chain, facilitating the transfer of electrons from NADH to ubiquinone and contributing to the generation of proton motive force essential for ATP synthesis. NDUFB2, as part of this complex, serves as an essential subunit involved in electron transfer processes. Inhibitors of NDUFB2 are designed to modulate the activity of complex I by specifically interfering with the function of NDUFB2, disrupting the electron transfer chain and subsequently affecting the overall mitochondrial function.
These inhibitors typically exhibit a high degree of selectivity towards NDUFB2, aiming to perturb the electron transport chain without significant impact on other cellular processes. The detailed molecular mechanisms underlying the inhibition of NDUFB2 involve binding interactions that hinder the normal functioning of the subunit. By disrupting the electron flow through complex I, NDUFB2 inhibitors may have implications for cellular bioenergetics and redox balance. Understanding the structural and biochemical aspects of these inhibitors can provide valuable insights into the intricacies of mitochondrial function and may pave the way for the development of novel strategies in research areas related to cellular metabolism and energy regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I, where NDUFB2 is a subunit. By binding to the complex, it prevents the transfer of electrons from iron-sulfur centers in the complex to ubiquinone, thereby reducing NDUFB2 activity within the electron transport chain. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $285.00 | 24 | |
Piericidin A, like rotenone, is a complex I inhibitor that disrupts the electron transfer by binding to the same site as ubiquinone. This directly decreases NDUFB2 function as part of the complex's activity. | ||||||
Dimethyl malonate | 108-59-8 | sc-239778 sc-239778A | 250 ml 1 L | $49.00 $102.00 | 1 | |
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (complex II). It indirectly affects NDUFB2 by altering the electron flow in the electron transport chain, which can modulate the activity of upstream complex I where NDUFB2 is located. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
TTFA is an inhibitor of complex II, which indirectly affects complex I. By inhibiting complex II, it decreases the ubiquinone pool, which is necessary for NDUFB2 function in complex I. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
Carboxin inhibits succinate dehydrogenase in complex II, leading to a decrease in the electron supply to ubiquinone. This indirectly impacts NDUFB2's activity in complex I due to the interconnectedness of the electron transport chain. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Chloramphenicol inhibits mitochondrial protein synthesis. As NDUFB2 is a protein component of complex I, this antibiotic reduces the functional assembly of the complex, thereby decreasing NDUFB2's activity. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin is an inhibitor of ATP synthase and blocks the proton channel within the enzyme. By diminishing proton flow, it indirectly reduces the activity of NDUFB2 in complex I due to the reduced proton motive force driving electron transport. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits complex III of the electron transport chain. This leads to a backup of electrons, which indirectly decreases NDUFB2 activity in complex I by reducing the flow of electrons through the chain. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $145.00 $450.00 | 11 | |
Capsazepine is a voltage-dependent anion channel inhibitor which can indirectly decrease the availability of ADP and thus reduce ATP synthesis. This indirectly affects NDUFB2 by disrupting the overall electron transport chain function and energy production in which NDUFB2 plays a role. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide inhibits complex IV of the electron transport chain. By interfering with the terminal electron acceptor, it reduces electron flow through the entire chain, including the complex I where NDUFB2 functions. | ||||||