NBS1 Activators
NBS1 Activators encompass a collection of chemical entities that indirectly enhance the functional activity of NBS1 within the cellular DNA damage response and repair systems. KU-55933 and AZD0156 act as ATM kinase inhibitors, which, by hindering the kinase's activity, inadvertently prompt a greater reliance on homologous recombination for DNA repair, a process in which NBS1 plays a pivotal role. Mirin and ETP-46464 similarly affect the MRN complex by inhibiting its exonuclease activity, thereby preventing the processing of DNA ends and enhancing the activation of NBS1 in checkpoint signaling and DNA repair. Chloroquine, through its inhibition of autophagy, indirectly stabilizes NBS1 by reducing its degradation, ensuring its availability for DNA damage signaling. NU7026, a DNA-PKcs inhibitor, and VE-821, an ATR inhibitor, both augment NBS1 function by increasing the cellular dependency on HR for the resolution of DNA damage, where NBS1's role is crucial.
Olaparib, Talazoparib, and Niraparib, all PARP inhibitors, enhance NBS1 activity by increasing the occurrence of DNA double-strand breaks that require NBS1-mediated repair through HR. The inhibition of Wip1 phosphatase by specific inhibitors keeps the DNA damage response activated longer, indirectly supporting the enhancement of NBS1's role in that response. Through these varied mechanisms, each chemical activator indirectly facilitates the enhancement of NBS1's involvement in the intricate network of pathways that maintain genomic stability. Collectively, they underscore the importance of NBS1's functional capacity in the cellular response to DNA damage, and their effects converge to amplify the critical activities of NBS1 in DNA repair processes.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol stimulates SIRT1, which in turn deacetylates NBS1, thereby enhancing its DNA repair activity. Increased SIRT1 activity enhances NBS1 functions in DNA damage response by promoting its recruitment to the sites of DNA breaks. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylases (HDACs), leading to hyperacetylation and relaxation of chromatin. This alteration in chromatin structure facilitates increased access of NBS1 to DNA lesions, enhancing its role in DNA repair mechanisms. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
As a precursor of NAD+, Nicotinamide Mononucleotide boosts the cellular NAD+ levels, which is required for the activity of SIRT1. By activating SIRT1, this compound indirectly enhances the deacetylation and activation of NBS1 in DNA damage response. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine disrupts lysosomal acidification, which can lead to the inhibition of autophagic degradation. This increases the stability and availability of proteins, such as NBS1, by preventing their autophagic degradation, thus potentially enhancing the DNA repair function. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
PARP inhibitors like Olaparib trap PARP on DNA lesions, leading to increased double-strand breaks. These breaks necessitate homologous recombination repair, where NBS1 is a critical component, thus indirectly promoting NBS1-mediated DNA repair activity. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
KU-55933 inhibits ATM Kinase, which, paradoxically, can lead to a compensatory increase in alternative DNA repair pathways involving NBS1. This indirect effect can enhance the NBS1-dependent repair mechanisms in response to double-strand breaks. | ||||||
MRN-ATM Pathway Inhibitor, Mirin | 299953-00-7 | sc-203144 | 10 mg | $138.00 | 4 | |
Mirin inhibits the MRE11-RAD50-NBS1 complex's exonuclease activity, which may enhance NBS1's roles in DNA repair checkpoint activation, as it shifts the complex's activity from DNA end resection towards activating the DNA damage response. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE-821 is an ATR inhibitor that, by inhibiting ATR, can lead to increased reliance on NBS1-mediated DNA repair pathways as a compensatory mechanism to maintain genomic stability in the face of DNA damage. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $350.00 | 10 | |
NU7441 is a DNA-PKcs inhibitor that can lead to an increase in homologous recombination repair activity where NBS1 is a key player. By inhibiting DNA-PKcs, the compound indirectly enhances NBS1's role in DNA repair. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can lead to the stabilization of proteins involved in DNA damage response, including NBS1, by preventing their degradation. Thus, MG132 enhances the availability of NBS1 for participating in DNA repair pathways. | ||||||