Date published: 2026-5-16

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NBPF8 Inhibitors

NBPF8 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the NBPF8 protein, a member of the neuroblastoma breakpoint family (NBPF). The NBPF family is a group of proteins primarily associated with human evolution and neurodevelopment. NBPF8, like other NBPF members, is thought to play a significant role in cell division, genomic stability, and regulation of protein expression. Inhibitors of NBPF8 interfere with its normal cellular functions, potentially by binding to key regions of the protein and preventing it from interacting with other molecules necessary for its activity. These inhibitors can act through various mechanisms, including direct binding to the active site of NBPF8 or altering its structure to impact its function.

The study of NBPF8 inhibitors is crucial for gaining deeper insights into the biological significance of NBPF8 and its role in cellular processes. By inhibiting the function of NBPF8, researchers can better understand its contributions to cell signaling, proliferation, and other pathways essential for maintaining proper cellular behavior. These inhibitors serve as important tools for dissecting the molecular pathways in which NBPF8 is involved, allowing for a clearer picture of how it contributes to normal and abnormal cellular functions. Additionally, NBPF8 inhibitors help researchers explore the evolutionary implications of the NBPF family, particularly in relation to human-specific developmental traits. Through continued research, the role of NBPF8 in broader biological systems can be elucidated, enhancing our knowledge of cell biology and protein regulation.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$74.00
$243.00
$731.00
$2572.00
$21848.00
53
(3)

Actinomycin D intercalates into DNA, inhibiting RNA polymerase and thus potentially decreasing gene expression.

α-Amanitin

23109-05-9sc-202440
sc-202440A
1 mg
5 mg
$269.00
$1050.00
26
(2)

α-Amanitin is a potent inhibitor of RNA polymerase II, which could reduce mRNA synthesis of genes like NBPF8.

Triptolide

38748-32-2sc-200122
sc-200122A
1 mg
5 mg
$90.00
$204.00
13
(1)

Triptolide is known to inhibit transcriptional activity by affecting RNA polymerase II, which could downregulate gene expression.

DRB

53-85-0sc-200581
sc-200581A
sc-200581B
sc-200581C
10 mg
50 mg
100 mg
250 mg
$43.00
$189.00
$316.00
$663.00
6
(1)

DRB is an adenosine analog that inhibits RNA polymerase II transcription elongation, potentially lowering gene expression.

Flavopiridol

146426-40-6sc-202157
sc-202157A
5 mg
25 mg
$78.00
$259.00
41
(3)

Flavopiridol inhibits cyclin-dependent kinases, which are necessary for RNA polymerase II-mediated transcription.

(±)-JQ1

1268524-69-1sc-472932
sc-472932A
5 mg
25 mg
$231.00
$863.00
1
(0)

JQ1 is a BET bromodomain inhibitor that displaces BET proteins from chromatin, affecting the expression of genes.

RG 108

48208-26-0sc-204235
sc-204235A
10 mg
50 mg
$131.00
$515.00
2
(1)

RG108 is a DNA methyltransferase inhibitor that can lead to demethylation of genes and potentially alter their expression.

Mithramycin A

18378-89-7sc-200909
1 mg
$55.00
6
(1)

Mithramycin A binds to GC-rich DNA sequences, inhibiting transcription factors from binding and thus can decrease gene expression.

C646

328968-36-1sc-364452
sc-364452A
10 mg
50 mg
$265.00
$944.00
5
(1)

C646 is a competitive inhibitor of p300/CBP histone acetyltransferases, which can alter gene expression patterns.

Sinefungin

58944-73-3sc-203263
sc-203263B
sc-203263C
sc-203263A
1 mg
100 mg
1 g
10 mg
$271.00
$5202.00
$40368.00
$704.00
4
(1)

Sinefungin is an inhibitor of S-adenosylmethionine-dependent methyltransferases, which could affect methylation status of genes and their expression.