NBC4 Activators
NBC4 Activators are a group of chemical compounds that enhance the functional activity of NBC4, a sodium/bicarbonate co-transporter that plays a critical role in maintaining intracellular pH. These activators influence various intracellular pathways to enhance the activity of NBC4. For instance, cyclic AMP (cAMP) and Forskolin enhance NBC4 activity by increasing intracellular cAMP levels, leading to the activation of protein kinase A (PKA), which phosphorylates and activates NBC4. Epinephrine, Dopamine, Glucagon, Isoproterenol, Histamine, and Serotonin also influence the cAMP pathway by binding to their respective receptors and activating adenylate cyclase, resulting in increased cAMP production. On the other hand, compounds like Insulin and Vasopressin affect the activity of NBC4 via different routes. Insulin activates the PI3K/Akt pathway, which leads to the phosphorylation and activation of NBC4, while Vasopressin activates phospholipase C, increasing intracellular calcium, which in turn activates NBC4.
Calcium Chloride also enhances the activity of NBC4 by increasing intracellular calcium levels, which can bind to and activate calmodulin, leading to the activation of NBC4. Theophylline, a member of the methylxanthines, inhibits phosphodiesterase, leading to an increase in cAMP levels, which then activates PKA and subsequently NBC4. Therefore, despite the diverse nature of these compounds and the pathways they influence, their ultimate impact converges on the activation of NBC4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
Cyclic AMP (cAMP) is a secondary messenger that can enhance the activity of NBC4 via its role in regulating intracellular pH. NBC4 is a sodium/bicarbonate co-transporter that functions to extrude intracellular acid. The production of cAMP can activate protein kinase A (PKA), which phosphorylates and activates NBC4, leading to an increase in bicarbonate transport and effectively removing excess intracellular acid. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to an increase in intracellular cAMP levels. As mentioned above, the production of cAMP activates PKA, which phosphorylates and activates NBC4, enhancing bicarbonate transport and effectively removing excess intracellular acid. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to β-adrenergic receptors, which signal through G-proteins to activate adenylate cyclase. This leads to the production of cAMP, activation of PKA, phosphorylation, and activation of NBC4, leading to an increase in bicarbonate transport and effectively removing excess intracellular acid. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/Akt pathway, which can phosphorylate and activate NBC4, leading to an increase in bicarbonate transport and effectively removing excess intracellular acid. | ||||||
Vasopressin | 11000-17-2 | sc-356188 sc-356188A | 5 mg 25 mg | $255.00 $1020.00 | 1 | |
Vasopressin binds to V1a receptors that signal through G-proteins to activate phospholipase C. This leads to the production of IP3 and DAG, which ultimately increase intracellular calcium. Calcium can bind to and activate calmodulin, which can activate NBC4, leading to an increase in bicarbonate transport and effectively removing excess intracellular acid. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium chloride can increase intracellular calcium levels. The elevated calcium can bind to and activate calmodulin, which can activate NBC4, leading to an increase in bicarbonate transport and effectively removing excess intracellular acid. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Theophylline inhibits phosphodiesterase, leading to an increase in cAMP levels. Higher cAMP levels activate PKA, which phosphorylates and activates NBC4, enhancing bicarbonate transport and effectively removing excess intracellular acid. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine binds to D1-like receptors, which signal through G-proteins to activate adenylate cyclase. This leads to the production of cAMP, activation of PKA, phosphorylation, and activation of NBC4, leading to an increase in bicarbonate transport and effectively removing excess intracellular acid. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol binds to β-adrenergic receptors, which signal through G-proteins to activate adenylate cyclase. This leads to the production of cAMP, activation of PKA, phosphorylation, and activation of NBC4, leading to an increase in bicarbonate transport and effectively removing excess intracellular acid. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine binds to H2 receptors, which signal through G-proteins to activate adenylate cyclase. This leads to the production of cAMP, activation of PKA, phosphorylation, and activation of NBC4, leading to an increase in bicarbonate transport and effectively removing excess intracellular acid. | ||||||