NAT-14 Inhibitors

NAT-14 inhibitors, compounds with varied structural motifs, including both synthetic molecules and naturally occurring compounds, can modulate enzyme activity through different mechanisms. Many of these compounds act by binding directly to the active site of the enzyme, thereby preventing the binding and subsequent acetylation of the enzyme's natural substrates. Examples of such inhibitors include 3-Amino-1,2,4-triazole, which binds directly to the enzyme's active site, and Sulfamethazine, an antibiotic that competes with substrate binding.

Another common mechanism involves the modification of the enzyme's structure, leading to reduced or entirely inhibited activity. Bis-(2-chloroethyl)amine, for instance, is an alkylating agent that can inhibit N-acetyltransferase activity by modifying the enzyme's active site. Additionally, flavonoids like Quercetin and Fisetin, found abundantly in various plants, exhibit inhibitory properties against certain N-acetyltransferases. They typically achieve this through their capability to interact and bind with the enzyme's structure.