Napsin A Inhibitors
Napsin A inhibitors belong to a class of chemical compounds that have gained significance in the fields of molecular biology and modulate specific cellular processes. Napsin A is an aspartic protease enzyme predominantly found in the human lung and is known for its role in the cleavage of specific substrates, particularly in the context of protein maturation and turnover. It plays a crucial role in the processing of certain precursor proteins, including the cleavage of surfactant protein B (SP-B) and surfactant protein C (SP-C), which are essential for the proper functioning of lung surfactant. Napsin A inhibitors are designed to interact with the active site or binding domain of the Napsin A enzyme, effectively inhibiting its proteolytic function and influencing cellular processes dependent on Napsin A-mediated substrate processing.
Structurally, Napsin A inhibitors are meticulously engineered to selectively target the active site of Napsin A, ensuring high specificity for this particular protease. By inhibiting Napsin A, these compounds may disrupt its role in the processing of precursor proteins, leading to alterations in the maturation of key proteins involved in lung surfactant function. The study of Napsin A inhibitors is of significant interest to researchers as it provides insights into the regulatory mechanisms governing essential cellular functions related to protein maturation and processing. This knowledge contributes to our understanding of basic cell biology and may have implications in various research areas, including lung development, pulmonary diseases, and the molecular basis of disorders associated with defective protein processing in the lungs. However, further research is required to fully explore the extent of their applications and their impact on cellular physiology in the context of Napsin A-mediated substrate processing.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Sirolimus inhibits the mTOR pathway, which is involved in the regulation of protein synthesis and cell proliferation. This inhibition could potentially downregulate the transcription of genes like Napsin A. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that can lead to the accumulation of misfolded proteins, triggering a stress response that may downregulate the expression of certain genes, including Napsin A. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables that is known to affect gene expression through the activation of Nrf2 and can modulate the expression of a range of genes, possibly including those encoding for proteases such as Napsin A. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a constituent of turmeric, is known to modulate transcription factors and has been shown to affect the expression of a variety of genes. It could theoretically influence the expression of Napsin A. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol acts as an antioxidant and has the potential to modulate gene expression through sirtuin activation. This modulation could potentially affect the transcription of genes like Napsin A. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG), found in green tea, has been associated with the modulation of multiple cellular pathways and gene expression profiles, potentially including those related to Napsin A. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits DNA topoisomerase II, which can cause DNA damage and potentially affect the expression of various genes, potentially including those coding for proteases such as Napsin A. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin forms DNA adducts and can affect transcription factor binding as well as mRNA synthesis, which might lead to altered gene expression, including that of Napsin A. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to a reduction in deoxyribonucleotide pools and affecting DNA synthesis. This disruption can influence the expression of various genes, including those related to proteases such as Napsin A. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone can alter gene expression profiles by antagonizing mineralocorticoid receptors, which could theoretically result in the downregulation of genes like that of Napsin A. | ||||||