Inhibiteurs Myotubularin (MTM, MTMR)
Myotubularin is a phosphoinositide phosphatase primarily involved in the regulation of membrane trafficking and signaling pathways within cells. It plays a significant role in muscle cell physiology by modulating the phosphatidylinositol 3-phosphate (PI3P) levels in membrane dynamics and signaling. Myotubularin is crucial for the proper functioning of muscle cells, including their development and differentiation. In muscle cell differentiation, myotubularin interacts with various signaling pathways, such as the AKT/mTOR pathway, which are essential for muscle growth and regeneration. Its dysregulation is linked to muscle disorders, notably myotubular myopathy, underscoring its importance in muscle health.
Targeting myotubularin for disruption or inhibition offers potential avenues for muscle-related diseases, particularly those involving dysfunctional membrane trafficking or signaling. Small molecule inhibitors could be designed to specifically target the enzymatic activity of myotubularin, potentially altering muscle cell development and maintenance.
VOIR ÉGALEMENT...
| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Ces derniers inhibent les phosphoinositides 3-kinases (PI3K), ce qui peut indirectement affecter le rôle de la myotubularine dans le métabolisme des phosphoinositides. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
Principalement un inhibiteur de l'autophagie qui cible PI3K, il pourrait indirectement influencer la fonction de la myotubularine dans la signalisation cellulaire. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Inhibiteur de l'Aurora kinase A qui, par ses effets plus larges sur le cycle cellulaire et la signalisation, peut avoir des impacts en aval sur les voies fonctionnelles de la myotubularine. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
Inhibe la signalisation Wnt en ciblant la β-caténine, un élément clé de la voie essentielle au développement musculaire. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Inhibe les récepteurs du TGF-β, affectant la différenciation des myoblastes. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $198.00 $650.00 | 16 | |
Un autre inhibiteur de la signalisation du TGF-β, qui peut avoir un impact sur la différenciation des cellules musculaires. | ||||||
BMS 493 | 215030-90-3 | sc-361124 sc-361124A | 10 mg 50 mg | $450.00 $1400.00 | 7 | |
Inhibe la signalisation de l'acide rétinoïque, qui peut affecter la différenciation myogénique. | ||||||