Myotubularin (MTM, MTMR) Inhibitors
Myotubularin is a phosphoinositide phosphatase primarily involved in the regulation of membrane trafficking and signaling pathways within cells. It plays a significant role in muscle cell physiology by modulating the phosphatidylinositol 3-phosphate (PI3P) levels in membrane dynamics and signaling. Myotubularin is crucial for the proper functioning of muscle cells, including their development and differentiation. In muscle cell differentiation, myotubularin interacts with various signaling pathways, such as the AKT/mTOR pathway, which are essential for muscle growth and regeneration. Its dysregulation is linked to muscle disorders, notably myotubular myopathy, underscoring its importance in muscle health.
Targeting myotubularin for disruption or inhibition offers potential avenues for muscle-related diseases, particularly those involving dysfunctional membrane trafficking or signaling. Small molecule inhibitors could be designed to specifically target the enzymatic activity of myotubularin, potentially altering muscle cell development and maintenance.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
These inhibit phosphoinositide 3-kinases (PI3Ks), which can indirectly affect myotubularin's role in phosphoinositide metabolism. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
Primarily an autophagy inhibitor that targets PI3K, it could indirectly influence myotubularin's function in cellular signaling. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
An Aurora kinase A inhibitor that, through its broader effects on cell cycle and signaling, may have downstream impacts on myotubularin's functional pathways. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
Inhibits Wnt signaling by targeting β-catenin, a key component in the pathway essential for muscle development. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Inhibits TGF-β receptors, affecting myoblast differentiation. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
Another inhibitor of TGF-β signaling, which can impact muscle cell differentiation. | ||||||
BMS 493 | 215030-90-3 | sc-361124 sc-361124A | 10 mg 50 mg | $459.00 $1428.00 | 7 | |
Inhibits retinoic acid signaling, which can affect myogenic differentiation. | ||||||