Myosin IXb Inhibitors
Myosin IXb inhibitors are a class of chemical compounds designed to target and modulate the activity of the Myosin IXb protein, also known as Myosin-9b or Myo9b. Myosin IXb is a member of the myosin superfamily of molecular motor proteins, which are involved in various cellular processes, including intracellular transport, cell motility, and the regulation of actin cytoskeleton dynamics. Specifically, Myosin IXb is an unconventional myosin that plays a role in actin filament dynamics and membrane trafficking within cells. Inhibitors of Myosin IXb are developed to interact with this motor protein, disrupting its function and affecting the processes it participates in.
Myosin IXb inhibitors are typically small molecules or compounds designed to bind to specific regions of the Myosin IXb protein, interfering with its motor activity or its interactions with actin filaments, membranes, or associated proteins. By doing so, these inhibitors may influence intracellular transport, actin cytoskeleton dynamics, or membrane trafficking processes that are regulated by Myosin IXb. Research into Myosin IXb inhibitors is essential for understanding the molecular mechanisms underlying these cellular processes and the role of Myosin IXb in maintaining cellular homeostasis. The insights gained from studying these inhibitors may contribute to a deeper understanding of the complex regulation of intracellular transport and cytoskeletal dynamics within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin can inhibit DNA-dependent RNA polymerase, potentially reducing transcription of genes such as Myosin IXb. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine intercalates into DNA and RNA, which may disrupt transcription and translation affecting Myosin IXb expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin is a potent inhibitor of RNA polymerase II, which can lead to decreased mRNA synthesis, including that of Myosin IXb. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and may inhibit RNA synthesis, potentially reducing the transcription of Myosin IXb. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $163.00 $316.00 | 436 | |
Puromycin causes premature chain termination during translation, potentially decreasing Myosin IXb protein synthesis. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin selectively inhibits DNA polymerase, which can lead to reduced replication and transcription, affecting Myosin IXb expression. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B blocks nuclear export of certain proteins, possibly influencing Myosin IXb mRNA or protein localization and stability. | ||||||
β-Lapachone | 4707-32-8 | sc-200875 sc-200875A | 5 mg 25 mg | $110.00 $450.00 | 8 | |
β-Lapachone is known to cause oxidative stress which may affect various signaling pathways, potentially decreasing Myosin IXb expression. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin interferes with peptide chain elongation, inhibiting protein synthesis and potentially affecting Myosin IXb expression. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol inhibits multiple cyclin-dependent kinases, potentially altering cell cycle progression and gene expression, including Myosin IXb. | ||||||