myomesin-1 Inhibitors
Myomesin-1 inhibitors represent a class of chemical compounds designed to modulate the activity of myomesin-1, a protein crucial for maintaining the structural integrity of the sarcomere in striated muscle cells. Myomesin-1, also known as myosin- and titin-binding protein-C (Myomesin-1), plays a pivotal role in the organization of sarcomeric M- and C-lines and is integral to the assembly of thick filaments within muscle fibers. The inhibition of myomesin-1 involves targeting specific binding sites or enzymatic activities associated with its function, thereby disrupting the protein's normal regulatory pathways.
myomesin-1 inhibitors is grounded in a comprehensive understanding of the molecular interactions and structural features that govern the protein's activity. Researchers often employ techniques such as structure-based drug design and high-throughput screening to identify small molecules that can selectively bind to myomesin-1, impeding its normal functions. These inhibitors may act through various mechanisms, including interference with protein-protein interactions, disruption of conformational changes essential for myomesin-1 function, or modulation of its enzymatic activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, which can affect multiple signaling pathways that may indirectly alter the function of proteins like MYOM1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 is an inhibitor of p38 MAP kinase, which may have downstream effects on the structural dynamics of proteins in muscle cells, including MYOM1. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can affect protein turnover, potentially influencing the stability of proteins like MYOM1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which could affect the AKT signaling pathway and subsequently modulate the function or expression of muscle-related structural proteins such as MYOM1. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which, by affecting the ERK pathway, could influence the structural integrity of muscle cells and proteins like MYOM1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key regulator of protein synthesis, which could have indirect effects on the expression of muscle structural proteins like MYOM1. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor, known to affect protein degradation pathways that could indirectly affect MYOM1 stability. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor, which could modulate cytoskeletal dynamics and potentially impact proteins like MYOM1 in muscle cells. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a c-RAF kinase inhibitor, which might have downstream effects on signaling pathways that could affect the stability or expression of MYOM1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which could modify the signaling pathways that indirectly influence the function of structural proteins like MYOM1. | ||||||