myomesin-1 Antibody (4F5): sc-293303

myomesin-1 Antibody (4F5) is a mouse monoclonal IgG1 kappa light chain antibody that detects myomesin-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-myomesin-1 antibody (4F5) is available as the non-conjugated format. Myomesin-1 plays a crucial role in the structural integrity of muscle fibers, as myomesin-1 is a key component of the myofibrillar M band, where myomesin-1 interacts with other important proteins such as Titin, Myosin, and Connectin. This interaction is vital for maintaining the organization and elasticity of the sarcomere, the fundamental unit of muscle contraction. The unique N-terminal domains of myomesin-1 and myomesin-2, which are predominantly expressed in skeletal muscle, contribute to the formation of a head structure that connects the Z and M bands of the sarcomere, ensuring proper muscle function and force generation. The gene encoding human myomesin-1 is located on chromosome 18p11.31-p11.32, highlighting myomesin-1′s significance in muscle biology and potential implications in muscle-related diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

myomesin-1 Antibody (4F5) References:

1. A novel marker for vertebrate embryonic heart, the EH-myomesin isoform.  |  Agarkova, I., et al. 2000. J Biol Chem. 275: 10256-64. PMID: 10744711
2. Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle.  |  Porter, JD., et al. 2003. J Exp Biol. 206: 3101-12. PMID: 12878677
3. Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein.  |  Hornemann, T., et al. 2003. J Mol Biol. 332: 877-87. PMID: 12972258
4. A new 185,000-dalton skeletal muscle protein detected by monoclonal antibodies.  |  Grove, BK., et al. 1984. J Cell Biol. 98: 518-24. PMID: 6537951
5. The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins.  |  Vinkemeier, U., et al. 1993. J Cell Sci. 106 (Pt 1): 319-30. PMID: 7505783
6. Assignment of the human gene for the sarcomeric M-band protein myomesin (MYOM1) to 18p11.31-p11.32.  |  Speel, EJ., et al. 1998. Genomics. 54: 184-6. PMID: 9806852

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-myomesin-1 Antibody (4F5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-myomesin-1 Antibody (4F5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

myomesin-1 Antibody (4F5) Specifications

Alternate Product Name: myomesin-1

Product Clone Name: 4F5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1586-1684

Epitope Target: myomesin-1

Epitope Species: human

Product Reactivity/Detection: myomesin-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for myomesin-1 Antibody (4F5): N/A