MYL2 Inhibitors
Regarding the chemical class of MYL2 Inhibitors, these compounds represent a diverse group with varying mechanisms of action. While none of them directly inhibit MYL2, they can indirectly influence its function through various pathways involved in muscle contraction and cellular signaling. For instance, inhibitors like Blebbistatin and ML-7 target the myosin-actin interaction and myosin light chain kinase, respectively, both crucial for muscle contraction and thus indirectly affecting MYL2 activity.
Other compounds, such as W-7 and KN-93, interfere with calcium signaling, a key regulator of MYL2 phosphorylation and activity. Calcium signaling is central to muscle contraction, and any alteration in this pathway can significantly impact MYL2 function. Similarly, compounds like Forskolin and Dantrolene affect adenylate cyclase activity and calcium release, respectively, further illustrating the indirect approaches to modulating MYL2 activity.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Inhibits myosin II activity; can indirectly affect MYL2 function in muscle contraction. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
Inhibits myosin light chain kinase; could reduce phosphorylation and activity of MYL2. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor; might indirectly affect MYL2 by altering muscle contraction pathways. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
Calmodulin antagonist; can disrupt calcium signaling, indirectly influencing MYL2 function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Broad-spectrum kinase inhibitor; could indirectly inhibit kinases that phosphorylate MYL2. | ||||||
2,3-Butanedione 2-Monoxime | 57-71-6 | sc-203774 sc-203774A sc-203774B sc-203774C | 25 g 100 g 250 g 500 g | $42.00 $78.00 $161.00 $286.00 | ||
Reduces force of contraction; might affect MYL2 function indirectly. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
Inhibits Ca2+/calmodulin-dependent protein kinase II; can affect MYL2 phosphorylation. | ||||||
H-7, Dihydrochloride | 108930-17-2 | sc-24009 sc-24009A | 10 mg 50 mg | $80.00 $319.00 | ||
Protein kinase inhibitor; could indirectly influence MYL2 phosphorylation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, leading to changes in muscle contraction and potentially affecting MYL2. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $92.00 $256.00 | 5 | |
Bisphosphonate; can affect calcium homeostasis, indirectly influencing MYL2 function. | ||||||