Molecular structure of H-7, Dihydrochloride, CAS Number: 108930-17-2
H-7, Dihydrochloride (CAS 108930-17-2)
Alternate Names:
1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride
Application:
H-7, Dihydrochloride is an ATP-competitive Ser/Thr kinase inhibitor
CAS Number:
108930-17-2
Purity:
≥98%
Molecular Weight:
364.29
Molecular Formula:
C14H17N3O2S•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
H-7, Dihydrochloride is a cell-permeable, reversible, ATP-competitive Ser/Thr kinase inhibitor. H-7 is a broad spectrum kinase inhibitor that may act to inhibit MYLK (MLCK) (Ki=97 muM), cAMP-dependent protein kinase (PKA) (Ki = 3.0 uM), Protein Kinase C (PKC) (Ki = 6.0 uM), and cGMP-dependent protein kinase (cGKI, PKG) (Ki = 5.8 uM). H-7 inhibits cell invasion and metastasis in B16BL6 cancer cells through the PKC/MEK/ERK pathway. This compound is shown to inhibit Topo I and II in murine L929 cells and induce apoptosis through PKC inhibition.
H-7, Dihydrochloride (CAS 108930-17-2) References
- Pretreatment with PKC inhibitor triggers TNF-alpha induced apoptosis in TNF-alpha-resistant B16 melanoma BL6 cells. | Nishida, S., et al. 2003. Life Sci. 74: 781-92. PMID: 14654170
- The structure and biological activities of the widely used protein kinase inhibitor, H7, differ depending on the commercial source. | Quick, J., et al. 1992. Biochem Biophys Res Commun. 187: 657-63. PMID: 1530623
- The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2. | Tsubaki, M., et al. 2007. Clin Exp Metastasis. 24: 431-8. PMID: 17636410
- Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. | Hidaka, H., et al. 1984. Biochemistry. 23: 5036-41. PMID: 6238627
- 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase C in rabbit platelets. | Kawamoto, S. and Hidaka, H. 1984. Biochem Biophys Res Commun. 125: 258-64. PMID: 6239622
- Modulation of topoisomerase activities by tumor necrosis factor. | Baloch, Z., et al. 1995. Cell Immunol. 160: 98-103. PMID: 7842491
Inhibitor of:
4930428D18Rik, Calponin 1, CaMK, LEO1, MYL2, MYLK, Naglt1a, PKA, PKC, RPAP3, SART-3, Ser/Thr Protein Kinase, SNAPC 45, TFIIA-β, and THAP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
H-7, Dihydrochloride, 10 mg | sc-24009 | 10 mg | $80.00 | |||
H-7, Dihydrochloride, 50 mg | sc-24009A | 50 mg | $319.00 |