Myelin P2 Inhibitors
Myelin P2 inhibitors are a class of chemical compounds that specifically target the Myelin P2 protein, a peripheral myelin protein involved in the structure and function of myelin sheaths in the peripheral nervous system. Myelin P2 is a member of the fatty acid-binding protein (FABP) family and plays a key role in stabilizing the myelin membrane by binding to fatty acids and interacting with lipids within the myelin sheath. This protein contributes to the compaction and insulation properties of myelin, which is essential for the rapid transmission of nerve impulses along axons. Inhibitors of Myelin P2 interfere with its lipid-binding capacity or disrupt its structural interactions within the myelin sheath, potentially altering the organization of myelin and affecting the overall integrity of the myelin membrane.
The design of Myelin P2 inhibitors focuses on identifying small molecules that can bind to the lipid-binding domain of the protein, preventing it from associating with fatty acids or interacting with the surrounding myelin lipids. These inhibitors may also work by destabilizing the protein's conformation, hindering its role in the compaction of the myelin sheath. Structural studies of Myelin P2 have provided detailed insights into its lipid-binding pocket and its interactions with other myelin components, guiding the development of specific inhibitors that target these regions. Researchers use Myelin P2 inhibitors to investigate the molecular mechanisms underlying myelin structure and stability, offering valuable insights into how the organization of myelin sheaths is maintained at a molecular level. These inhibitors help explore the role of Myelin P2 in lipid metabolism within myelin and its contribution to the broader processes of nerve insulation and signal conduction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide, a cyclic peptide isolated from marine sponges, disrupts actin dynamics by stabilizing F-actin filaments. In the context of Myelin P2 inhibition, it indirectly influences the protein by interfering with cytoskeletal rearrangements critical for the protein's intracellular trafficking and membrane association. The stabilization of actin filaments disrupts the dynamic equilibrium essential for Myelin P2's proper subcellular localization, thus impeding its functionality. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542 is a selective inhibitor of the TGF-β type I receptor kinase, crucial in the TGF-β signaling pathway. By blocking this kinase, SB-431542 indirectly impacts Myelin P2, which is influenced by TGF-β signaling. TGF-β's downstream effects on myelination processes involve Myelin P2, and inhibiting the TGF-β receptor kinase hinders this signaling cascade, ultimately leading to decreased Myelin P2 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a fungal metabolite, functions as a potent phosphoinositide 3-kinase (PI3K) inhibitor. PI3K is involved in various cellular processes, including those associated with Myelin P2. Inhibition of PI3K by Wortmannin disrupts downstream pathways regulating Myelin P2 expression and function, impacting the protein's involvement in myelination processes. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A, found in fungi, inhibits the function of ADP-ribosylation factor (ARF) and disrupts the Golgi apparatus. Myelin P2 is known to traffic through the secretory pathway, and Brefeldin A impedes this process by affecting vesicular transport. Consequently, Myelin P2 fails to reach its intended destination, hindering its normal function in the myelination process. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3Ks), impacting signaling cascades crucial for Myelin P2 regulation. By disrupting PI3K activity, LY294002 interferes with downstream pathways modulating Myelin P2 expression and subcellular localization. This leads to a compromised functionality of Myelin P2 in myelination processes due to altered intracellular dynamics and signaling cascades. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 acts as a potent and reversible inhibitor of c-Jun N-terminal kinases (JNK). Since JNK signaling intersects with pathways involving Myelin P2, SP600125 disrupts the normal regulation of Myelin P2 by modulating JNK-dependent cellular processes. This interference leads to alterations in Myelin P2 expression and function, affecting its contribution to myelination processes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, impacts cellular processes related to Myelin P2 regulation. By inhibiting mTOR, Rapamycin disrupts downstream signaling cascades involved in the modulation of Myelin P2 expression and function. The protein's role in myelination processes is consequently compromised due to altered cellular dynamics resulting from the inhibition of mTOR-dependent pathways. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506, also known as Tacrolimus, functions as an immunosuppressive agent by inhibiting calcineurin. Myelin P2 is indirectly regulated by calcineurin-dependent pathways, and FK506 disrupts this regulation. The inhibition of calcineurin by FK506 leads to altered downstream signaling cascades influencing Myelin P2 expression and function, thereby affecting its contribution to myelination processes. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187, a calcium ionophore, indirectly influences Myelin P2 through calcium-dependent signaling pathways. Myelin P2 activity is modulated by calcium-dependent processes, and A23187 disrupts this regulation. The elevation of intracellular calcium levels by A23187 leads to altered downstream signaling cascades affecting Myelin P2 expression and function, ultimately impacting its role in myelination processes. | ||||||
LY 303511 | 154447-38-8 | sc-202215 sc-202215A | 1 mg 5 mg | $67.00 $278.00 | 3 | |
LY303511, an inactive analog of LY294002, acts as a negative control for PI3K inhibition. By serving as a control, LY303511 helps elucidate the specific impact of PI3K inhibition on Myelin P2 regulation. This compound aids in confirming the role of PI3K-dependent pathways in influencing Myelin P2 expression and function, providing valuable insights into the intricate regulatory mechanisms governing myelination processes. | ||||||