MUP8 Inhibitors
MUP8 inhibitors are compounds that specifically target Major Urinary Protein 8 (MUP8), a member of the Major Urinary Protein family, which plays a role in the binding and transport of volatile pheromones in rodents. MUPs, including MUP8, act as carriers for small, hydrophobic molecules, particularly pheromones, facilitating their release into the environment and enhancing communication between individuals. MUP8 is involved in the complex signaling systems that influence behaviors such as territorial marking, mating, and social recognition. By inhibiting MUP8, these inhibitors block its ability to bind to and transport pheromones, disrupting the chemical signals that are integral to these social and behavioral processes.
In research, MUP8 inhibitors are valuable tools for studying the structure-function relationships of MUP proteins and their role in the behavioral biology of animals, particularly rodents. These inhibitors allow researchers to probe the specific function of MUP8 in pheromone-mediated communication and investigate how inhibiting MUP8 affects pheromone release, detection, and the subsequent behavioral responses. The use of MUP8 inhibitors helps to explore the broader biological implications of pheromone signaling and provides insights into how different MUPs contribute to the nuanced communication systems of animals. Additionally, these inhibitors support structural studies, helping to elucidate the critical binding regions of MUP8 and its interaction with specific pheromones, furthering our understanding of the molecular mechanisms that underlie animal behavior.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Inhibits GPCR signaling crucial for Mup8's predicted function in the extracellular space. Pertussis Toxin disrupts GPCR signaling, indirectly inhibiting Mup8, potentially altering its role in extracellular processes. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Targets Matrix Metalloproteinases (MMPs), influencing Extracellular Matrix (ECM) remodeling. Indirectly inhibits Mup8 by modulating ECM, potentially impacting the protein's role in the extracellular environment. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Blocks SERCA, affecting intracellular calcium homeostasis. Indirectly inhibits Mup8's predicted function in the extracellular space by influencing calcium-dependent signaling pathways. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Induces calcium influx by facilitating ion transport across the cell membrane. Ionomycin disrupts intracellular calcium homeostasis, indirectly inhibiting Mup8 in the extracellular space by influencing calcium-dependent signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K/AKT pathway associated with Mup8. LY294002 disrupts PI3K/AKT signaling, indirectly affecting Mup8 in the extracellular space and potentially modulating its predicted function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
Targets the MEK/ERK pathway influencing Mup8's predicted function in the extracellular space. U0126 disrupts MEK/ERK signaling, indirectly inhibiting Mup8, potentially altering its role in extracellular processes. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
Specifically inhibits Rac1, a GTPase involved in cytoskeletal reorganization. NSC 23766 indirectly inhibits Mup8, potentially impacting its predicted function in the extracellular space by affecting GTPase signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Inhibits MEK in the MAPK/ERK pathway associated with Mup8. PD98059 disrupts this pathway, indirectly affecting Mup8 in the extracellular space and potentially modulating its predicted function. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
Targets Raf-1 kinase in the Ras/Raf/MEK/ERK pathway associated with Mup8. GW5074 disrupts this pathway, indirectly inhibiting Mup8, potentially altering its role in extracellular processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Irreversible PI3K inhibitor affecting Mup8. Wortmannin disrupts PI3K/AKT signaling, indirectly influencing Mup8 in the extracellular space and potentially modulating its predicted function. | ||||||