Multimerin-1 Activators
Multimerin-1 activators are a class of chemical compounds that interact with the protein Multimerin-1, a large, soluble extracellular matrix protein that is known to be involved in cell adhesion and is stored within the platelets and endothelial cells. These activators can be both of natural origin or synthetically produced and are characterized by their ability to initiate a biochemical cascade that leads to the activation of Multimerin-1. The mechanism of action for these activators can vary; some may bind directly to the protein, inducing a conformational change that results in its activation. Others may function indirectly by modulating the cellular environment or interacting with other molecules or cofactors that influence Multimerin-1 activity.
The activation of Multimerin-1 by these chemicals can have multiple downstream effects due to the protein's role in the extracellular matrix and its involvement in cell adhesion processes. When activated, Multimerin-1 may influence the organization of the extracellular matrix, potentially affecting the behavior of cells and their interactions with the matrix. The exact biochemical pathways and the implications of Multimerin-1 activation are areas of active research, with scientists exploring the detailed molecular interactions and the potential cellular responses to these activations. The study of Multimerin-1 activators is primarily rooted in the understanding of cellular and molecular biology, with a focus on the elucidation of physiological pathways and the potential for modulating cellular functions. By dissecting the activation mechanisms of Multimerin-1, researchers aim to gain insights into the complex interplay between cells and the extracellular matrix, which is a fundamental aspect of cellular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine stimulates the adrenergic receptors, which can lead to an increase in intracellular calcium concentrations. Multimerin-1, being a calcium-binding adhesive protein, can be influenced by this rise in calcium, leading to an increase in its activity or concentration. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Similar to Epinephrine, Norepinephrine can also stimulate adrenergic receptors, leading to an increase in intracellular calcium levels. This can indirectly stimulate Multimerin-1 due to its calcium-binding properties. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can increase the levels of cyclic AMP, which further leads to the activation of Protein Kinase A (PKA). PKA can phosphorylate a range of proteins, including those involved in the secretion pathway that Multimerin-1 is part of. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through its receptor, can lead to an increase in intracellular calcium levels. As Multimerin-1 binds to calcium, this can indirectly stimulate its activity or concentration. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $116.00 $183.00 | 15 | |
Serotonin, through its receptor, can increase the levels of cyclic AMP, which further activates PKA. PKA can phosphorylate proteins involved in the secretion pathway that Multimerin-1 is part of. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases the levels of cyclic AMP, activating PKA. PKA phosphorylates proteins that are part of the secretion pathway, potentially enhancing the secretion and activity of Multimerin-1. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium chloride can increase extracellular and intracellular calcium levels, which can influence Multimerin-1 activity due to its calcium-binding properties. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Ionophore A23187 is a mobile ion-carrier that forms a complex with calcium ions to transport them across the cell membrane, increasing intracellular calcium levels and potentially influencing Multimerin-1 activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase, leading to an increase in cytoplasmic calcium concentration, potentially influencing the activity of Multimerin-1. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, a calcium channel blocker, has been shown to increase the intracellular calcium concentration, potentially influencing Multimerin-1 activity. | ||||||