Mucin 22 Inhibitors
Chemical inhibitors of Mucin 22 can interfere with its glycosylation process, which is pivotal for its function. Benzyl-α-GalNAc acts as a competitive inhibitor, resembling the natural substrates of the enzyme responsible for O-glycosylation. Tunicamycin, on the other hand, targets N-linked glycosylation, preventing the addition of glycan groups that are crucial for the protein's stability and function. Similarly, castanospermine and deoxynojirimycin target the initial steps of N-glycan processing by inhibiting glucosidases, with the latter specifically targeting α-glucosidases and thereby impeding the maturation of Mucin 22. Deoxymannojirimycin and kifunensine specifically inhibit mannosidases involved in N-glycan processing, affecting the maturation sequence of Mucin 22. Swainsonine disrupts the action of Golgi α-mannosidase II, which is essential for the modification of N-glycans, leading to improper glycan structures on Mucin 22.
Additionally, compounds such as Brefeldin A and Monensin disrupt the Golgi apparatus, where Mucin 22 undergoes critical processing. Brefeldin A disassembles the Golgi structure, while Monensin alters the Golgi's pH and ion gradients, both leading to a misprocessed Mucin 22. Nojirimycin, another glucosidase inhibitor, prevents the correct folding and maturation of Mucin 22 by interfering with the glycan processing. Lastly, NB-DNJ (Miglustat) inhibits the enzyme glucosylceramide synthase, which can indirectly affect the processing of glycoproteins like Mucin 22 by disrupting the synthesis of glycosphingolipids that are involved in proper folding and trafficking of the protein. Each of these compounds, through their specific mechanisms, can inhibit the proper glycosylation and maturation of Mucin 22, leading to a functional inhibition of the protein.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside | 3554-93-6 | sc-203427 sc-203427A | 100 mg 1 g | $350.00 $3122.00 | 2 | |
Benzyl-α-GalNAc acts as an inhibitor of O-glycosylation by serving as a substrate mimic. By competing with the natural substrates of mucin-type O-glycosylation, it can lead to the functional inhibition of Mucin 22 glycosylation. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation. Mucin 22 undergoes glycosylation as a post-translational modification, which is essential for its function. Inhibition of glycosylation can lead to the functional inhibition of Mucin 22. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $135.00 $246.00 $619.00 $799.00 $1796.00 | 6 | |
Swainsonine inhibits Golgi α-mannosidase II, an enzyme involved in the trimming of N-glycans in the Golgi apparatus. Inhibition of this enzyme can disrupt proper glycosylation of Mucin 22, thereby inhibiting its function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts Golgi apparatus structure and function. Since Mucin 22 is processed and modified in the Golgi, this disruption can inhibit the proper processing and maturation of Mucin 22, leading to its functional inhibition. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that disrupts Golgi function by altering pH and ion gradients. The altered Golgi environment can inhibit the processing of glycoproteins like Mucin 22, which is essential for its function. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $180.00 $620.00 | 10 | |
Castanospermine inhibits glucosidases, which are involved in the initial steps of N-glycan processing. By inhibiting these enzymes, the glycosylation and proper folding of Mucin 22 can be hindered, leading to its functional inhibition. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $72.00 $142.00 | ||
Deoxynojirimycin inhibits α-glucosidases, which are crucial for the trimming of N-linked glycans during glycoprotein maturation. Inhibition of these enzymes can functionally inhibit the maturation of Mucin 22. | ||||||
Deoxymannojirimycin hydrochloride | 84444-90-6 | sc-201360 sc-201360A | 1 mg 5 mg | $93.00 $239.00 | 2 | |
Deoxymannojirimycin inhibits mannosidases, which are involved in the processing of N-linked glycans. By doing so, it can functionally inhibit the proper maturation and function of Mucin 22. | ||||||
Kifunensine | 109944-15-2 | sc-201364 sc-201364A sc-201364B sc-201364C | 1 mg 5 mg 10 mg 100 mg | $132.00 $529.00 $1005.00 $6125.00 | 25 | |
Kifunensine inhibits mannosidase I, an enzyme responsible for N-glycan processing. The inhibition of this enzyme can lead to improper glycan processing on Mucin 22, resulting in its functional inhibition. | ||||||