Mucin 20 Activators
Mucin 20 Activators comprise a diverse group of chemical compounds that can enhance the functional activity of Mucin 20 through various specific signaling pathways. For instance, Forskolin and Isoproterenol elevate cyclic AMP (cAMP) levels by activating adenylyl cyclase and beta-adrenergic receptors, respectively. Given Mucin 20's downstream status in the cAMP pathway, its expression can be enhanced by these compounds. Similarly, Epinephrine and Acetylcholine can enhance the functional activity of Mucin 20 by increasing intracellular calcium levels through the activation of adrenergic and muscarinic receptors, respectively.
On the other hand, compounds such as Phorbol 12-myristate 13-acetate (PMA) can activate Protein Kinase C (PKC), resulting in the phosphorylation of downstream proteins that interact with Mucin 20, thereby enhancing its functional activity. Compounds like Uridine triphosphate (UTP) and Nicotinamide adenine dinucleotide (NAD) also increase intracellular calcium levels, thereby enhancing the functional activity of Mucin 20, by activating P2Y receptors and ADP-ribosyl cyclases, respectively. Moreover, Indomethacin inhibits Cyclooxygenase (COX) enzymes, which shifts the cellular metabolic pathway towards lipoxygenase products that can influence the functional activity of Mucin 20. Lastly, Dexamethasone, 2-Aminoethyl diphenylborinate (2-APB), Thapsigargin, and Prostaglandin E2 (PGE2) can influence the expression and function of Mucin 20 through glucocorticoid-responsive elements in the Mucin 20 gene promoter, inhibition of IP3 receptors, inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), and activation of the prostaglandin E2 receptor EP4 subtype, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a potent activator of adenylyl cyclase, leading to increased cyclic AMP (cAMP) levels. Elevated cAMP levels can enhance Mucin 20 expression, as Mucin 20 is downstream of the cAMP pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). Activation of PKC can lead to the phosphorylation of downstream proteins that interact with Mucin 20, hence enhancing its functional activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine activates adrenergic receptors, which can increase intracellular calcium levels. Increased calcium levels can have an effect on Mucin 20, as it is known to be calcium responsive. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic receptor agonist, that increases cAMP levels. Enhanced cAMP levels can lead to increased expression of Mucin 20. | ||||||
Uridine-5′-triphosphate, Trisodium Salt | 19817-92-6 | sc-301964 sc-301964A | 50 mg 1 g | $86.00 $118.00 | 2 | |
UTP activates P2Y receptors leading to increased intracellular calcium levels. Enhanced calcium levels can boost the functional activity of Mucin 20. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD can activate ADP-ribosyl cyclases, leading to the production of cyclic ADP-ribose, which increases intracellular calcium levels. This enhances the functional activity of Mucin 20. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin inhibits Cyclooxygenase (COX) enzymes, attenuating the production of prostaglandins. This shifts the cellular metabolic pathway towards lipoxygenase products, which can influence the functional activity of Mucin 20. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid receptor agonist, that can influence the expression of a variety of proteins. It can enhance the functional activity of Mucin 20 through glucocorticoid-responsive elements in the promoter region of the Mucin 20 gene. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB inhibits IP3 receptors, thereby influencing calcium signaling. Given that Mucin 20 is calcium responsive, its functional activity can be enhanced by 2-APB. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels. This can enhance the functional activity of Mucin 20. | ||||||