MTF-2 Activators
MTF-2 Activators are a group of chemical compounds that specifically enhance the functional activity of MTF-2, a protein involved in gene regulation. These compounds act primarily by modifying the chromatin structure, namely through the inhibition of histone deacetylases and DNA methyltransferases, which leads to a more relaxed chromatin structure and decreased DNA methylation respectively. Compounds such as Trichostatin A, Sodium Butyrate, VPA, MS-275, SAHA (Suberoylanilide Hydroxamic Acid), and Mocetinostat inhibit histone deacetylases, leading to increased histone acetylation and a more open chromatin structure. This more relaxed structure allows MTF-2 to bind more effectively, enhancing its gene regulatory function.
Similarly, 5-Azacytidine, RG108, Zebularine, and Genistein are DNA methyltransferase inhibitors that decrease DNA methylation, potentially creating a more favorable environment for MTF-2 to bind and exert its gene regulatory function. DZNep and GSK343 are inhibitors of the histone methyltransferase EZH2, which can influence the methylation status of histones and affect the chromatin structure, thereby enhancing the functional activity of MTF-2. Therefore, these compounds can enhance the activity of MTF-2 by directly or indirectlymodulating the chromatin structure to increase MTF-2 accessibility and binding. On the other hand, DNA methyltransferase inhibitors, such as 5-Azacytidine, RG108, Zebularine, and Genistein, decrease DNA methylation levels. This reduction in methylation creates a more conducive environment for MTF-2 to bind to DNA and exert its gene regulatory function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a potent histone deacetylase inhibitor. By inhibiting histone deacetylase, it promotes the acetylation of histones, leading to a more relaxed chromatin structure that facilitates MTF-2 binding and its functional enhancement in gene regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate is a short-chain fatty acid that acts as a histone deacetylase inhibitor. It can increase the acetylation of histones, causing chromatin to be more open and accessible for MTF-2, thus enhancing its gene regulatory function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. It can reduce the methylation of DNA, potentially creating a more favorable environment for MTF-2 to bind to DNA and exert its gene regulatory function. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
VPA is a histone deacetylase inhibitor. By increasing histone acetylation, it makes chromatin more accessible for MTF-2, thereby enhancing the functional activity of MTF-2 in gene regulation. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a non-nucleoside inhibitor of DNA methyltransferases, decreasing DNA methylation and potentially providing a more favorable environment for MTF-2 to bind and regulate gene expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 is a specific inhibitor of class I histone deacetylases. It increases histone acetylation, leading to a more relaxed chromatin structure and facilitating the binding and functional enhancement of MTF-2. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
Zebularine is a DNA methyltransferase inhibitor, reducing DNA methylation and potentially creating a more favorable environment for MTF-2 to bind and regulate gene expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA is a potent inhibitor of histone deacetylases, promoting histone acetylation and a more open chromatin structure. This can enhance the functional activity of MTF-2 in gene regulation. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
Mocetinostat is an inhibitor of class I and IV histone deacetylases. By promoting histone acetylation, it can facilitate the binding and functional enhancement of MTF-2. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that also modulates DNA methylation. It can decrease DNA methylation, creating a more conducive environment for MTF-2 to bind and regulate gene expression. | ||||||