MTCP-1 Activators
MTCP-1 activators comprise a diverse set of chemical compounds that indirectly augment the functional activity of MTCP-1 through a variety of signaling pathways. Forskolin and FSK, both act by elevating intracellular cAMP levels, indirectly enhance MTCP-1's activity by activating PKA, which in turn may phosphorylate proteins that regulate or interact with MTCP-1, facilitating its function. Similarly, IBMX and Rolipram, as non-selective and selective phosphodiesterase inhibitors, respectively, increase cAMP levels, leading to PKA activation and potential enhancement of MTCP-1 activity. Isoproterenol, a β-adrenergic agonist, also raises cAMP levels, further supporting the potential enhancement of MTCP-1 activity through the same PKA-mediated phosphorylation mechanism. Sildenafil and Zaprinast, both PDE5 inhibitors, contribute to raised cAMP and cGMP levels, which may lead to PKA and PKG activation, respectively, offering potential phosphorylation routes for enhancing MTCP-1's activity.
PMA and Chelerythrine, acting through the modulation of PKC activity, represent another dimension of MTCP-1 activation; PMA as an activator and Chelerythrine as an inhibitor could modulate signaling pathways that involve MTCP-1, potentially enhancing its function. Ionomycin and A23187, by altering intracellular calcium levels, contribute to the activation of calcium-dependent signaling pathways, which may indirectly boost MTCP1_activity. Lastly, Y-27632, a ROCK inhibitor, could influence cytoskeletal dynamics, which may indirectly impact MTCP-1's role in related signaling processes, enhancing its activity without upregulating its expression.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can activate PKA. PKA may then phosphorylate proteins that interact with MTCP-1, enhancing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to increased cAMP levels and subsequent PKA activation which could enhance MTCP-1 activity by phosphorylation of associated proteins. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates Protein Kinase C (PKC), which can modulate the activity of proteins that may form complexes with MTCP-1, potentially enhancing its function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
By increasing intracellular calcium levels, ionomycin can activate calcium-dependent kinases that may indirectly enhance MTCP-1 activity through phosphorylation of proteins in associated signaling pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits PDE4 and results in elevated cAMP, which activates PKA. PKA could then enhance MTCP-1 activity by phosphorylating associated proteins. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a β-adrenergic agonist that increases cAMP and activates PKA. PKA may phosphorylate proteins that regulate MTCP-1 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as a calcium ionophore, raising intracellular calcium concentration and possibly enhancing MTCP-1 activity by activating calcium-dependent signaling pathways. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast inhibits PDE5, leading to increased cGMP levels which may activate PKG. PKG could enhance MTCP-1 activity by influencing signaling pathways that involve MTCP-1. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine is a PKC inhibitor that could enhance MTCP-1 activity by modulating signaling pathways involving PKC that interact with MTCP-1. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits ROCK, which could lead to changes in cytoskeletal dynamics and potentially enhance MTCP-1's role in related signaling pathways. | ||||||