MT-MMP-1 Activators
MT-MMP-1 activators are a subset of molecules that exert their influence on a specific member of the matrix metalloproteinase (MMP) family, known as Membrane-Type Matrix Metalloproteinase-1 (MT-MMP-1). MMPs are a group of enzymes that play crucial roles in remodeling the extracellular matrix, a complex network of proteins that provide structural support to tissues in the body. MT-MMP-1, in particular, is of interest due to its unique location and function. Unlike other MMPs, it is anchored to the cell membrane, allowing it to interact with the extracellular matrix and cell surface receptors. MT-MMP-1 activators are compounds or molecules that modulate the activity of this specific enzyme, influencing its ability to degrade and remodel components of the extracellular matrix.
The activation of MT-MMP-1 is a finely regulated process that involves the cleavage of its proenzyme form to the active enzyme. MT-MMP-1 activators may act at different stages of this activation process. These molecules can enhance the activation of MT-MMP-1, potentially increasing its ability to degrade specific extracellular matrix components, such as collagen and proteoglycans. This regulation of MT-MMP-1 activity is vital for various physiological and pathological processes, including tissue development, wound healing, and tissue remodeling in diseases like cancer and arthritis. Understanding the mechanisms and effects of MT-MMP-1 activators at the molecular level is essential for unraveling their role in tissue homeostasis and disease progression, which can have implications for future research in various fields, including biology, cell biology, and pharmacology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC is an antioxidant and a precursor to glutathione. It has been shown to inhibit MT-MMP-1 activity by reducing reactive oxygen species (ROS) levels, which can otherwise activate MT-MMP-1. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
GM6001 is a broad-spectrum MMP inhibitor; however, in sub-inhibitory concentrations, it may paradoxically enhance MT-MMP 1 activity by binding to its active site, leading to conformational changes that expose its catalytic domain. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Similar to GM6001, Batimastat in low doses could potentially induce a conformational change in MT-MMP 1, resulting in increased enzymatic activity by making the active site more accessible. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a synthetic compound that activates protein kinase C (PKC), which in turn can stimulate the expression and activation of MT-MMP-It's commonly used in research to induce MT-MMP-1 expression. | ||||||
Doxycycline-d6 | 564-25-0 unlabeled | sc-218274 | 1 mg | $16500.00 | ||
At sub-antimicrobial doses, Doxycycline may enhance MT-MMP 1 activity indirectly by inhibiting other MMPs, thus reducing substrate competition. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Heparin can bind to MT-MMP 1 and facilitate its dimerization, which is associated with increased proteolytic activity of this enzyme. | ||||||
Collagen IV | sc-29010 | 1 mg | $224.00 | 11 | ||
Collagen, as a natural substrate of MT-MMP 1, can enhance its activity simply by providing the substrate that MT-MMP 1 acts upon, thus facilitating its proteolytic function. | ||||||