MT-MMP-1 Antibody (C-7): sc-377097

MT-MMP-1 Antibody (C-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects MT-MMP-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MT-MMP-1 antibody (C-7) is specific for an epitope mapping between amino acids 83-119 near the N-terminus of MT-MMP-1 of human origin. MT-MMP-1 (C-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The matrix metalloproteinases (MMP) family, to which MT-MMP-1 belongs, plays a crucial role in the degradation of extracellular matrix components, such as collagen and gelatin, which is vital for tissue remodeling and repair processes. MT-MMP-1 monoclonal antibody (C-7), also known as MMP-14, is a type I membrane protein that not only degrades extracellular matrix components but also activates other MMPs, thereby regulating the turnover of the extracellular matrix. MT-MMP-1 (C-7) antibody activation is mediated by proprotein convertases, indicating involvement in a cascade that is essential for maintaining tissue homeostasis and responding to pathological conditions. Understanding MT-MMP-1 function and regulation is important for elucidating roles in various diseases, including cancer metastasis and tissue fibrosis, making anti-MT-MMP-1 antibody (C-7) a valuable tool for researchers studying these processes.

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MT-MMP-1 Antibody (C-7) References:

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2. Centrosomal BRCA2 is a target protein of membrane type-1 matrix metalloproteinase (MT1-MMP).  |  Wali, N., et al. 2014. Biochem Biophys Res Commun. 443: 1148-54. PMID: 24384087
3. MMP-14 in skeletal muscle repair.  |  Snyman, C. and Niesler, CU. 2015. J Muscle Res Cell Motil. 36: 215-25. PMID: 26025393
4. MEMBRANE TYPE 1-MATRIX METALLOPROTEINASE (MT1-MMP) IDENTIFIED AS A MULTIFUNCTIONAL REGULATOR OF VASCULAR RESPONSES.  |  Ohkawara, H., et al. 2015. Fukushima J Med Sci. 61: 91-100. PMID: 26370683
5. miR-181 suppresses metastasis via MMP-14.  |  Roth, E. and Cao, J. 2015. Aging (Albany NY). 7: 740-1. PMID: 26527609
6. SLFN5 suppresses cancer cell migration and invasion by inhibiting MT1-MMP expression via AKT/GSK-3β/β-catenin pathway.  |  Wan, G., et al. 2019. Cell Signal. 59: 1-12. PMID: 30844429
7. Furin-dependent intracellular activation of the human stromelysin-3 zymogen.  |  Pei, D. and Weiss, SJ. 1995. Nature. 375: 244-7. PMID: 7746327
8. Tumour biology. Membrane proteases in focus.  |  Vassalli, JD. and Pepper, MS. 1994. Nature. 370: 14-5. PMID: 8015594
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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MT-MMP-1 Antibody (C-7) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-MT-MMP-1 Antibody (C-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MT-MMP-1 Antibody (C-7) Specifications

Alternate Product Name: MMP14

Product Clone Name: C-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 83-119

Epitope Target: MT-MMP-1

Epitope Species: human

Product Reactivity/Detection: MT-MMP-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for MT-MMP-1 Antibody (C-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin